Lee D H, Li K, Suh D H
Department of Dermatology, Seoul National University College of Medicine, 28 Yongon-Dong, Chongno-Gu, Seoul 110-744, Korea.
Br J Dermatol. 2008 May;158(5):1069-76. doi: 10.1111/j.1365-2133.2008.08496.x. Epub 2008 Mar 20.
Steroid-induced rosacea is a relatively common dermatosis that is caused by the prolonged application of topical steroid to the face.
The purpose of this investigator-blind, split-face study was to evaluate the efficacy and safety of pimecrolimus 1% cream for the treatment of steroid-induced rosacea.
PATIENTS/METHODS: Patients were instructed to apply pimecrolimus 1% cream twice daily to the involved areas of a randomly allocated half side for the first 2 weeks, and to follow this by applying pimecrolimus 1% cream to both sides for a further 6 weeks.
Fifteen of the 18 patients completed the 8-week study. After 1 week of application, a statistically significant improvement was observed for investigator's global assessments of erythema and papules on prior-treated sides (P-side). Later-treated sides (L-side) showed subsequent improvement after use of pimecrolimus on the L-side. Likewise, a statistically significant improvement was also observed for numbers of papules/pustules on P-sides after 1 week, and L-sides showed a significant improvement after application of pimecrolimus on the L-side. Comparative reflectance colorimetric assessments revealed that DeltaL*, Deltaa* and Deltab* tended to converge to zero during the first 4 weeks. A statistically significant improvement was observed for percentage area affected on P-sides after 1 week of application. The L-side showed a significant improvement after use of pimecrolimus cream on that side. The visual analogue scale of P-sides decreased more rapidly than those of L-sides. Cutaneous side-effects were mild and transient.
This study suggests that pimecrolimus 1% cream is an effective and well-tolerated treatment for steroid-induced rosacea.
类固醇诱导的酒渣鼻是一种相对常见的皮肤病，由长期对面部使用外用类固醇引起。
本研究者盲法、半脸研究的目的是评估1%吡美莫司乳膏治疗类固醇诱导的酒渣鼻的疗效和安全性。
患者/方法：患者被指示在最初2周每天两次将1%吡美莫司乳膏涂抹于随机分配的半侧受累区域，之后在接下来的6周将1%吡美莫司乳膏涂抹于双侧。
18例患者中有15例完成了为期8周的研究。用药1周后，研究者对先前治疗侧（P侧）红斑和丘疹的整体评估有统计学显著改善。后治疗侧（L侧）在L侧使用吡美莫司后随后出现改善。同样，用药1周后P侧丘疹/脓疱数量也有统计学显著改善，L侧在L侧使用吡美莫司后有显著改善。比较反射比色法评估显示，在最初4周内ΔL*、Δa和Δb趋于收敛至零。用药1周后P侧受影响面积百分比有统计学显著改善。L侧在该侧使用吡美莫司乳膏后有显著改善。P侧的视觉模拟评分比L侧下降得更快。皮肤副作用轻微且短暂。
本研究表明，1%吡美莫司乳膏是治疗类固醇诱导的酒渣鼻的一种有效且耐受性良好的疗法。
