Pulmonary Department, Heart Institute, University of São Paulo Medical School, São Paulo, Brazil.
Expert Rev Respir Med. 2011 Oct;5(5):675-81. doi: 10.1586/ers.11.58.
Schistosomiasis is one of the most prevalent chronic infectious diseases in the world. One of its most severe complications, pulmonary hypertension, occurs in up to 5% of patients with hepatosplenic schistosomiasis. The prevalence of schistosomiasis is so overwhelming that schistosomiasis-associated pulmonary hypertension (Sch-PH) may be the most prevalent cause of pulmonary hypertension around the world. Multiple pathways have been described as potential mechanisms of disease in Sch-PH, such as egg embolism, inflammatory disease or pulmonary blood overflow. The possible physiopathological mechanisms will be discussed in this article, as well the disease's clinical course and response to the treatment available.
血吸虫病是世界上最流行的慢性传染病之一。其最严重的并发症之一是肺动脉高压，在肝脾血吸虫病患者中高达 5%。血吸虫病的流行程度如此之高，以至于血吸虫病相关的肺动脉高压（Sch-PH）可能是全球最常见的肺动脉高压病因。已经描述了多种可能的疾病发病机制途径，例如虫卵栓塞、炎症性疾病或肺血溢出。本文将讨论可能的病理生理机制，以及疾病的临床过程和对现有治疗的反应。
