The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Expert Rev Respir Med. 2011 Oct;5(5):699-709. doi: 10.1586/ers.11.55.
miRNAs are a recently discovered category of small noncoding RNAs that regulate gene expression at the post-transcriptional level. Altered expressions of miRNAs are reported in a variety of human cancers and may associate with cancer pathogenesis, apoptosis and cell growth, thereby functioning as either oncogenes or tumor suppressors. Accumulating evidence indicates that deregulation of miRNA contributes to tumor initiation and progression and hence, has clinical value in several human cancers, including non-small-cell lung cancer. This article discusses the current knowledge of miRNAs in risk assessment, prevention, early diagnosis, prognosis and their possible role as oncogenes or tumor suppressors in the pathogenesis of non-small-cell lung cancer.
miRNAs 是一类新发现的小非编码 RNA，可在转录后水平调节基因表达。miRNAs 的表达异常已在多种人类癌症中报道，并可能与癌症发病机制、细胞凋亡和生长有关，从而作为癌基因或抑癌基因发挥作用。越来越多的证据表明，miRNA 的失调导致肿瘤的发生和进展，因此在几种人类癌症中具有临床价值，包括非小细胞肺癌。本文讨论了 miRNA 在非小细胞肺癌的风险评估、预防、早期诊断、预后以及作为癌基因或抑癌基因在发病机制中可能的作用的最新知识。
