定期运动可增加循环内皮祖细胞的数量和活性，从而减轻健康男性随增龄导致的动脉弹性下降。
Regular exercise-induced increased number and activity of circulating endothelial progenitor cells attenuates age-related decline in arterial elasticity in healthy men.
机构信息
Department of Hypertension and Vascular Disease, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou 510080, China.
出版信息
Int J Cardiol. 2013 May 10;165(2):247-54. doi: 10.1016/j.ijcard.2011.08.055. Epub 2011 Sep 28.
BACKGROUND
Deficiency in number and activity of circulating EPCs is associated with reduced arterial elasticity in humans with advancing aging. Physical exercise can increase the number and activity of circulating EPCs in humans. Here we investigated whether regular exercise-induced enhanced circulating endothelial progenitor cells (EPCs) improves age-related decline in arterial elasticity in healthy men.
METHODS
In a cross-sectional study, the number and activity of circulating EPCs as well as brachial-ankle pulse wave velocity (baPWV) of young and older sedentary or endurance-trained healthy men were studied. Then we observed the effect of regular exercise on circulating EPCs and baPWV of 10 older and 10 young sedentary healthy men.
RESULTS
In both sedentary and endurance-trained men, the number and activity of circulating EPCs were significantly low in older men compared with young men, which was paralleled to increased baPWV. After three months of regular exercise, the number and activity of circulating EPCs increased, and the baPWV of 10 older and 10 young sedentary healthy men decreased. However, the increased number and activity of circulating EPCs and decreased baPWV of older sedentary healthy men were higher. There was a close correlation between circulating EPCs and baPWV. Multivariate analysis identified proliferative activity of circulating EPCs as an independent predictor of baPWV.
CONCLUSIONS
The present study demonstrates for the first time that regular physical exercise-induced enhanced circulating EPCs attenuates age-related decline in arterial elasticity in healthy men. These findings provide novel insights into the protective effects of exercise on age-related vascular injury.
背景
循环内皮祖细胞（EPCs）数量和活性的减少与人类衰老过程中动脉弹性的降低有关。体育锻炼可以增加人类循环 EPCs 的数量和活性。在这里，我们研究了定期运动引起的循环内皮祖细胞（EPCs）的增加是否可以改善健康男性的动脉弹性随年龄增长而下降的情况。
方法
在一项横断面研究中，研究了年轻和年老久坐或耐力训练的健康男性循环 EPCs 的数量和活性以及肱踝脉搏波速度（baPWV）。然后，我们观察了定期运动对 10 名年老和 10 名年轻久坐健康男性循环 EPCs 和 baPWV 的影响。
结果
在久坐和耐力训练的男性中，与年轻男性相比，年老男性的循环 EPCs 数量和活性明显较低，这与 baPWV 增加相平行。经过三个月的定期运动，循环 EPCs 的数量和活性增加，10 名年老和 10 名年轻久坐健康男性的 baPWV 降低。然而，年老久坐健康男性循环 EPCs 数量和活性的增加以及 baPWV 的降低幅度更高。循环 EPCs 与 baPWV 之间存在密切的相关性。多变量分析确定循环 EPCs 的增殖活性是 baPWV 的独立预测因子。
结论
本研究首次证明，定期体育锻炼引起的循环 EPCs 增强可减轻健康男性动脉弹性随年龄增长而下降的程度。这些发现为运动对与年龄相关的血管损伤的保护作用提供了新的见解。
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