Li Wei, Chen Lingzhen, Mohammad Sajadi S, Baghaei Sh, Salahshour Soheil
Department of Sports Medicine, Fourth Medical Center of PLA General Hospital, Beijing 100048, China.
Department of Sports and Arts, Zhejiang Gongshang University HangZhou College of Commerce, No. 66, South Huancheng Road, Tonglu, Hangzhou, China.
Regen Ther. 2024 May 7;27:464-481. doi: 10.1016/j.reth.2024.04.013. eCollection 2024 Dec.
Stem cells (SCs) play a crucial role in tissue repair, regeneration, and maintaining physiological homeostasis. Exercise mobilizes and enhances the function of SCs. This review examines the effects of acute and chronic aerobic and resistance exercise on the population of SCs in healthy and diseased individuals across different age groups. Both acute intense exercise and moderate regular training increase circulating precursor cells CD34 and, in particular, the subset of angiogenic progenitor cells (APCs) CD34+/KDR+. Conversely, chronic exercise training has conflicting effects on circulating CD34 cells and their function, which are likely influenced by exercise dosage, the health status of the participants, and the methodologies employed. While acute activity promotes transient mobilization, regular exercise often leads to an increased number of progenitors and more sustainable functionality. Short interventions lasting 10-21 days mobilize CD34+/KDR + APCs in sedentary elderly individuals, indicating the inherent capacity of the body to rapidly activate tissue-reparative SCs during activity. However, further investigation is needed to determine the optimal exercise regimens for enhancing SC mobilization, elucidating the underlying mechanisms, and establishing functional benefits for health and disease prevention. Current evidence supports the integration of intense exercise with chronic training in exercise protocols aimed at activating the inherent regenerative potential through SC mobilization. The physical activity promotes endogenous repair processes, and research on exercise protocols that effectively mobilize SCs can provide innovative guidelines designed for lifelong tissue regeneration. An artificial neural network (ANN) was developed to estimate the effects of modifying elderly individuals and implementing chronic resistance exercise on stem cell mobilization and its impact on individuals and exercise. The network's predictions were validated using linear regression and found to be acceptable compared to experimental results.
干细胞在组织修复、再生及维持生理稳态中发挥着关键作用。运动可调动并增强干细胞的功能。本综述探讨了急性和慢性有氧运动及抗阻运动对不同年龄组健康个体和患病个体干细胞数量的影响。急性高强度运动和适度的常规训练均可增加循环前体细胞CD34数量，尤其是血管生成祖细胞（APC）CD34+/KDR+亚群。相反，慢性运动训练对循环CD34细胞及其功能的影响存在矛盾，这可能受运动剂量、参与者健康状况及所采用方法的影响。虽然急性运动可促进短暂的调动，但规律运动通常会导致祖细胞数量增加及功能更持久。持续10 - 21天的短期干预可调动久坐不动的老年人的CD34+/KDR + APC，这表明身体在运动期间具有快速激活组织修复性干细胞的内在能力。然而，需要进一步研究以确定增强干细胞调动的最佳运动方案，阐明潜在机制，并确定对健康和疾病预防的功能益处。目前的证据支持在旨在通过干细胞调动激活内在再生潜力的运动方案中，将高强度运动与慢性训练相结合。体育活动可促进内源性修复过程，对有效调动干细胞的运动方案的研究可为终身组织再生提供创新性指导方针。开发了一种人工神经网络（ANN）来估计改变老年人及实施慢性抗阻运动对干细胞调动的影响及其对个体和运动的影响。该网络的预测结果通过线性回归得到验证，与实验结果相比是可接受的。
