National Research Lab for RNA Cell Biology, BK21 Graduate Program for RNA Biology and Department of Molecular Biology, Dankook University, Gyeonggi-do 448-701, South Korea.
Wiley Interdiscip Rev RNA. 2010 Nov-Dec;1(3):486-93. doi: 10.1002/wrna.23.
Stress granules (SGs) are aggregates of translationally silenced messenger ribonucleoprotein (mRNP) complexes induced by oxidative, osmotic, hypoxic, thermal, viral, and genotoxic stresses. Over the past decade, extensive research has identified key components of SGs, their molecular interactions, and impact on stress-induced reprogramming of protein expression and cell survival. However, studies defining the signaling pathways that modulate SG assembly have only been launched recently. These studies reveal that posttranslational modifications of selected SG proteins play important roles in the regulation of SG assembly and function. Here we provide an overview of the signaling pathways and posttranslational protein modifications that regulate the assembly and function of SGs.
应激颗粒（SGs）是由氧化、渗透、缺氧、热、病毒和基因毒性应激诱导产生的翻译沉默信使核糖核蛋白（mRNP）复合物聚集体。在过去十年中，广泛的研究已经确定了应激颗粒的关键成分、它们的分子相互作用，以及对应激诱导的蛋白质表达重编程和细胞存活的影响。然而，关于调控应激颗粒组装的信号通路的研究直到最近才开始。这些研究表明，特定应激颗粒蛋白的翻译后修饰在应激颗粒组装和功能的调节中发挥着重要作用。在这里，我们概述了调控应激颗粒组装和功能的信号通路以及蛋白质翻译后修饰。
