Cholakova R, Stanilov Kh, Aleksiev N
Vet Med Nauki. 1978;15(7):19-26.
Simultaneous vaccination was carried out of day-old chicks against Marek's disease (strain C3--1) and Newcastle disease (strains B1 and La Sota) which did not prove to be effective in conferring a lasting immunity to Newcastle disease though it was tolerated without any disturbances whatever. One could resort to it by way of an exception only, with an obligatory revaccination 15 days later, when the unfavourable epizootic status made it necessary. The immunity built up against Marek's disease did not seem to be affected by the simultaneous or succeeding vaccination against Newcastle disease with live lentogenic strains. Effective in conferring solid immunity against Newcastle disease proved the combined application of the two vaccines in the following order: treatment of day-old chicks with a vaccine against Marek's disease and vaccination of the same chicks at the age of 8 days with a vaccine against Newcastle disease (strain B1) at a half rate, employing the spray method, followed by revaccination 15 days later with the La Sota vaccine at a full rate, employing the aerosol method.
对一日龄雏鸡同时接种马立克氏病疫苗(C3 - 1株)和新城疫疫苗(B1株和La Sota株),结果表明,这种方法虽能被雏鸡耐受且无任何干扰,但对新城疫并未产生持久免疫力。只有在特殊情况下,且疫病流行状况不利、有必要时,才可采用这种方法,并在15天后进行强制再接种。用弱毒活疫苗同时或先后接种新城疫疫苗,似乎并未影响针对马立克氏病建立的免疫力。按以下顺序联合使用两种疫苗可有效提供针对新城疫的可靠免疫力:用马立克氏病疫苗处理一日龄雏鸡,8日龄时对同一批雏鸡以半量、采用喷雾法接种新城疫疫苗(B1株),15天后再以全量、采用气雾法接种La Sota疫苗进行再接种。