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乳酸乳球菌NCC 2287通过特异性降低回肠中白细胞介素-13的表达来减轻致敏小鼠的食物过敏表现。

Lactococcus lactis NCC 2287 alleviates food allergic manifestations in sensitized mice by reducing IL-13 expression specifically in the ileum.

作者信息

Zuercher Adrian W, Weiss Marietta, Holvoet Sébastien, Moser Mireille, Moussu Hélène, van Overtvelt Laurence, Horiot Stéphane, Moingeon Philippe, Nutten Sophie, Prioult Guénolée, Singh Anurag, Mercenier Annick

机构信息

Allergy Group, Department of Nutrition and Health, Nestle Research Center, Vers-chez-les-Blanc, 1000 Lausanne 26, Switzerland.

出版信息

Clin Dev Immunol. 2012;2012:485750. doi: 10.1155/2012/485750. Epub 2011 Sep 22.

DOI:10.1155/2012/485750
PMID:21961022
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3179883/
Abstract

OBJECTIVE

Utilizing a food allergy murine model, we have investigated the intrinsic antiallergic potential of the Lactococcus lactis NCC 2287 strain.

METHODS

BALB/c mice were sensitized at weekly intervals with ovalbumin (OVA) plus cholera toxin (CT) by the oral route for 7 weeks. In this model, an oral challenge with a high dose of OVA at the end of the sensitization period leads to clinical symptoms. Lactococcus lactis NCC 2287 was given to mice via the drinking water during sensitization (prevention phase) or after sensitization (management phase).

RESULTS

Lactococcus lactis NCC 2287 administration to sensitized mice strikingly reduced allergic manifestations in the management phase upon challenge, when compared to control mice. No preventive effect was observed with the strain. Lactococcus lactis NCC 2287 significantly decreased relative expression levels of the Th-2 cytokine, IL-13, and associated chemokines CCL11 (eotaxin-1) and CCL17 (TARC) in the ileum. No effect was observed in the jejunum.

CONCLUSION/SIGNIFICANCE: These results taken together designate Lactococcus lactis NCC 2287 as a candidate probiotic strain appropriate in the management of allergic symptoms.

摘要

目的

利用食物过敏小鼠模型，我们研究了乳酸乳球菌NCC 2287菌株的内在抗过敏潜力。

方法

BALB/c小鼠每周经口用卵清蛋白（OVA）加霍乱毒素（CT）致敏，持续7周。在该模型中，致敏期结束时用高剂量OVA进行口服激发会导致临床症状。在致敏期间（预防阶段）或致敏后（管理阶段）通过饮用水将乳酸乳球菌NCC 2287给予小鼠。

结果

与对照小鼠相比，在激发后的管理阶段，将乳酸乳球菌NCC 2287给予致敏小鼠可显著降低过敏表现。该菌株未观察到预防作用。乳酸乳球菌NCC 2287显著降低了回肠中Th-2细胞因子IL-13以及相关趋化因子CCL11（嗜酸性粒细胞趋化因子-1）和CCL17（胸腺激活调节趋化因子）的相对表达水平。在空肠中未观察到作用。

结论/意义：综合这些结果表明，乳酸乳球菌NCC 2287是一种适用于管理过敏症状的候选益生菌菌株。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/324e/3179883/c9005c746049/CDI2012-485750.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/324e/3179883/10da4832e1ea/CDI2012-485750.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/324e/3179883/652ef813bd33/CDI2012-485750.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/324e/3179883/c9ce80670493/CDI2012-485750.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/324e/3179883/b5d55ab4d328/CDI2012-485750.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/324e/3179883/c9005c746049/CDI2012-485750.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/324e/3179883/10da4832e1ea/CDI2012-485750.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/324e/3179883/652ef813bd33/CDI2012-485750.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/324e/3179883/c9ce80670493/CDI2012-485750.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/324e/3179883/b5d55ab4d328/CDI2012-485750.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/324e/3179883/c9005c746049/CDI2012-485750.005.jpg

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本文引用的文献

1
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Clin Exp Allergy. 2010 Jun;40(6):942-50. doi: 10.1111/j.1365-2222.2010.03460.x. Epub 2010 Feb 17.
2
Interleukin-13 directly promotes oesophagus production of CCL11 and CCL24 and the migration of eosinophils.白细胞介素-13 直接促进食管产生 CCL11 和 CCL24，并促进嗜酸性粒细胞迁移。
Clin Exp Allergy. 2010 Mar;40(3):427-34. doi: 10.1111/j.1365-2222.2009.03419.x. Epub 2009 Dec 16.
3
Allergen-specific antibody and cytokine responses, mast cell reactivity and intestinal permeability upon oral challenge of sensitized and tolerized mice.
Front Microbiol. 2017 Nov 23;8:2247. doi: 10.3389/fmicb.2017.02247. eCollection 2017.
4
Polysaccharides L900/2 and L900/3 isolated from Lactobacillus rhamnosus LOCK 0900 modulate allergic sensitization to ovalbumin in a mouse model.从鼠李糖乳杆菌LOCK 0900中分离出的多糖L900/2和L900/3在小鼠模型中调节对卵清蛋白的过敏致敏作用。
Microb Biotechnol. 2017 May;10(3):586-593. doi: 10.1111/1751-7915.12606. Epub 2017 Feb 6.
5
House dust mite allergy: environment evaluation and disease prevention.屋尘螨过敏：环境评估与疾病预防
Asia Pac Allergy. 2014 Oct;4(4):241-52. doi: 10.5415/apallergy.2014.4.4.241. Epub 2014 Oct 29.
6
Recombinant Lactococcus lactis can make the difference in antigen-specific immune tolerance induction, the Type 1 Diabetes case.重组乳酸乳球菌在诱导抗原特异性免疫耐受（1型糖尿病病例）方面能发挥作用。
Microb Cell Fact. 2014 Aug 29;13 Suppl 1(Suppl 1):S11. doi: 10.1186/1475-2859-13-S1-S11.
7
Surface proteome analysis of a natural isolate of Lactococcus lactis reveals the presence of pili able to bind human intestinal epithelial cells.乳球菌天然分离株表面蛋白质组分析显示存在能够结合人肠道上皮细胞的菌毛。
Mol Cell Proteomics. 2013 Dec;12(12):3935-47. doi: 10.1074/mcp.M113.029066. Epub 2013 Sep 3.
8
Probiotics and food allergy.益生菌与食物过敏。
Ital J Pediatr. 2013 Jul 29;39:47. doi: 10.1186/1824-7288-39-47.
9
Probiotic therapy as a novel approach for allergic disease.益生菌治疗作为一种治疗过敏性疾病的新方法。
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致敏和耐受小鼠口服激发后的过敏原特异性抗体和细胞因子反应、肥大细胞反应和肠道通透性。
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4
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J Nutr. 2009 Jul;139(7):1398-403. doi: 10.3945/jn.109.108514. Epub 2009 May 27.
5
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FEMS Immunol Med Microbiol. 2009 Apr;55(3):324-34. doi: 10.1111/j.1574-695X.2008.00510.x.
6
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Int Arch Allergy Immunol. 2009;149(3):219-30. doi: 10.1159/000199717. Epub 2009 Feb 12.
7
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Mucosal Immunol. 2009 Jan;2(1):24-32. doi: 10.1038/mi.2008.72. Epub 2008 Oct 29.
8
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J Clin Gastroenterol. 2008 Sep;42 Suppl 3 Pt 1:S130-2. doi: 10.1097/MCG.0b013e318169c463.
10
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J Allergy Clin Immunol. 2008 Oct;122(4):788-794. doi: 10.1016/j.jaci.2008.07.011. Epub 2008 Aug 31.