Rocha Paulo M, Barata José T, Minderico Cláudia S, Silva Analiza M, Teixeira Pedro J, Sardinha Luís B
Exercise and Health Laboratory, Faculty of Human Movement, Technical University of Lisbon, Lisbon, Estrada da Costa, 1495-688 Cruz Quebrada, Portugal.
J Lipids. 2011;2011:154672. doi: 10.1155/2011/154672. Epub 2011 Sep 22.
Abdominal obesity has been associated with liver fat storage. However, the relationships between other body composition depots and metabolic syndrome features with hepatic fat are still unclear. We examined abdominal and thigh adipose tissue (AT) compartments associations with liver fat in 140 overweight and obese premenopausal Caucasian women. Blood lipids and, proinflammatory and atherothrombotic markers associations with hepatic fat were also analyzed. A larger visceral AT (VAT) was related with liver fat (P < 0.05). Contrarily, thigh subfascial AT was inversely related to liver fat (P < 0.05). Increased fasting insulin, triglycerides, PAI-1 concentrations, and a higher total-cholesterol/HDL-cholesterol ratio were also associated with hepatic fat, even after adjustment for VAT (P < 0.05). Thigh subfascial adiposity was inversely associated with liver fat, suggesting a potential preventive role against ectopic fat storage in overweight and obese women. These results reinforce the contribution of an abdominal obesity phenotype associated with a diabetogenic and atherothrombotic profile to liver lipotoxicity.
腹部肥胖与肝脏脂肪储存有关。然而，其他身体成分储存部位以及代谢综合征特征与肝脏脂肪之间的关系仍不明确。我们在140名超重和肥胖的绝经前白种女性中研究了腹部和大腿脂肪组织（AT）各部分与肝脏脂肪的关联。还分析了血脂以及促炎和动脉粥样硬化血栓形成标志物与肝脏脂肪的关联。较大的内脏脂肪组织（VAT）与肝脏脂肪相关（P < 0.05）。相反，大腿筋膜下脂肪组织与肝脏脂肪呈负相关（P < 0.05）。即使在对内脏脂肪组织进行校正后，空腹胰岛素、甘油三酯、纤溶酶原激活物抑制剂1（PAI - 1）浓度升高以及总胆固醇/高密度脂蛋白胆固醇比值升高也与肝脏脂肪有关（P < 0.05）。大腿筋膜下肥胖与肝脏脂肪呈负相关，提示对超重和肥胖女性异位脂肪储存具有潜在预防作用。这些结果强化了与致糖尿病和动脉粥样硬化血栓形成特征相关的腹部肥胖表型对肝脏脂毒性的影响。
