SISSA, Cognitive Neuroscience Sector, 34136 Trieste, Italy.
Neural Plast. 2011;2011:683961. doi: 10.1155/2011/683961. Epub 2011 Sep 26.
Theta oscillations are thought to play a critical role in neuronal information processing, especially in the hippocampal region, where their presence is particularly salient. A detailed description of theta dynamics in this region has revealed not only a consortium of layer-specific theta dipoles, but also within-layer differences in the expression of theta. This complex and articulated arrangement of current flows is reflected in the way neuronal firing is modulated in time. Several models have proposed that these different theta modulators flexibly coordinate hippocampal regions, to support associative memory formation and retrieval. Here, we summarily review different approaches related to this issue and we describe a mechanism, based on experimental and simulation results, for memory retrieval in CA3 involving theta modulation.
theta 振荡被认为在神经元信息处理中起着关键作用，特别是在海马区，其存在尤为明显。对该区域 theta 动力学的详细描述不仅揭示了一组特定于层的 theta 偶极子，还揭示了 theta 表达的层内差异。这种复杂而精细的电流流动排列反映在神经元发射随时间调制的方式上。有几个模型提出，这些不同的 theta 调制器灵活地协调海马区，以支持联想记忆的形成和检索。在这里，我们总结了与这个问题相关的不同方法，并描述了一种基于实验和模拟结果的机制，用于涉及 theta 调制的 CA3 中的记忆检索。
