Golitsyn S P
Ter Arkh. 2011;83(8):25-33.
The review of long-term international clinical experience with amiodaron covers pharmacological properties of the drug, mechanisms of development of its pharmacodynamic effects basing on its action on ionic channels, receptors, impact on thyroid function. Unique pharmacokinetics of amiodaron, high antiarrhythmic efficacy of the drug in supraventricular and ventricular arrhythmia, positive experience in primary and secondary prevention of sudden death are characterized. Amiodaron is effective in patients with atrial fibrillation including those with organic heart disease and chronic cardiac failure. It is safe in relation to different cardiac side effects which are minimal but has some non-cardiac side effects which require control during long-term treatment.
对胺碘酮长期国际临床经验的综述涵盖了该药物的药理学特性、基于其对离子通道、受体的作用以及对甲状腺功能的影响而产生药效学效应的机制。介绍了胺碘酮独特的药代动力学、该药物在室上性和室性心律失常方面的高抗心律失常疗效、在心脏性猝死一级和二级预防方面的积极经验。胺碘酮对包括患有器质性心脏病和慢性心力衰竭的患者在内的房颤患者有效。它在不同心脏副作用方面是安全的，这些副作用极小，但有一些非心脏副作用，在长期治疗期间需要加以控制。
