Vega-Sánchez Rodrigo, de Jesús-Torres Elizabeth, Arenas-Hernández Marcia, Beltrán-Montoya Jorge, Maida-Claros Rolando, Estrada-Gutiérrez Guadalupe, Vadillo-Ortega Felipe
Departamento de Investigación en Nutrición, Instituto Nacional de Parinatología Isidro Espinosa de los Reyes, México, DF.
Ginecol Obstet Mex. 2010 Dec;78(12):677-84.
The human labor is an inflammatory process invading leukocytes modulated by gestational tissues. The local increase of cell adhesion molecules (CAMs) promotes the permanence of these leukocytes in the coriodecidua. Gestational tissues express ICAM-1, while circulating leukocytes expressing its ligand Mac-1.
To analyze, first, if the expression of CAMs in the fetal membranes is associated with progress of gestational age, and second, the expression of CAMs on circulating leukocytes in the uterus (placenta).
original and closed study conducted at the Instituto Nacional de Perinatologia Isidro Espinosa de los Reyes (Mexico City). We included samples from healthy women between 15 and 44 years of age with term pregnancies (> or =37 weeks gestation).
Real time PCR analysis showed that the expression of CAMs in the fetal membranes remained constant before labor. ICAM3 and ICAM1 tended to increase during labor, while ICAM2, VCAM1, SELE and SELP decrease with advancing gestational age. Placental leukocytes showed a clear increase in the expression of ITGAM (Mac-1) during labor.
These results show that the maternal-fetal interface expresses a specific combination of CAMs during labor, including ICAM1, ICAM-3 and Mac-1. The expression of these molecules could promote the retention of leukocytes in the local tissues to modulate the local inflammatory microenvironment during human labor.
分娩是一个由妊娠组织调节的、涉及白细胞浸润的炎症过程。细胞黏附分子（CAMs）的局部增加促进了这些白细胞在蜕膜中的存留。妊娠组织表达细胞间黏附分子-1（ICAM-1），而循环白细胞表达其配体巨噬细胞-1抗原（Mac-1）。
首先分析胎膜中CAMs的表达是否与孕周进展相关，其次分析子宫（胎盘）中循环白细胞上CAMs的表达情况。
在墨西哥城伊西德罗·埃斯皮诺萨·德洛斯雷耶斯国家围产医学研究所进行的一项原始的、封闭性研究。我们纳入了年龄在15至44岁之间、足月妊娠（孕周≥37周）的健康女性的样本。
实时聚合酶链反应（PCR）分析显示，胎膜中CAMs的表达在分娩前保持恒定。细胞间黏附分子-3（ICAM3）和ICAM1在分娩期间有增加趋势，而ICAM2、血管细胞黏附分子-1（VCAM1）、E-选择素（SELE）和P-选择素（SELP）随孕周增加而降低。胎盘白细胞在分娩期间ITGAM（Mac-1）的表达明显增加。
这些结果表明，母胎界面在分娩期间表达特定的CAMs组合，包括ICAM1、ICAM-3和Mac-1。这些分子的表达可能促进白细胞在局部组织中的存留，从而在分娩期间调节局部炎症微环境。
