Department of Obstetrics and Gynecology, University of Colorado School of Medicine, 12631 East 17th Avenue, Aurora, CO 80045, USA.
Obstet Gynecol Clin North Am. 2011 Sep;38(3):455-66. doi: 10.1016/j.ogc.2011.05.004.
The hormonal correlates of reproductive aging and the menopause transition reflect an initial loss of the follicle cohort, while a responsive ovary remains, and an eventual complete loss of follicle response, with persistent hypergonadotropic amenorrhea. The physiology of the process is described, along with key findings of relevant studies, with an emphasis on the Study of Women's Health Across the Nation. A clinical framework is provided to help clinicians to forecast the major milestones of the menopausal transition and to predict potential symptoms or disease.
生殖衰老和绝经过渡的激素相关变化反映了卵泡库的初始丢失，而有反应的卵巢仍然存在，最终完全丧失卵泡反应，出现持续高促性腺激素性闭经。本文描述了这一过程的生理学，并介绍了相关研究的重要发现，重点介绍了全国妇女健康研究。提供了一个临床框架，以帮助临床医生预测绝经过渡的主要里程碑，并预测潜在的症状或疾病。
