Bimonte-Nelson Heather A, Bernaud Victoria E
Department of Psychology, Arizona State University, 950 S. McAllister Ave., Tempe, AZ 85287, USA.
Arizona Alzheimer's Consortium, 4745 N 7th St, Phoenix, AZ 85014, USA.
Curr Opin Endocr Metab Res. 2023 Feb;28. doi: 10.1016/j.coemr.2023.100434. Epub 2023 Jan 13.
Midlife in women typically includes the menopausal transition, a time of hormonal transformation, adaptation, and reorganization. Coincident with this dynamic period of physiological change, there are putatively modifiable factors that influence disease, short-term and long-term health outcomes, symptom emergence, and longevity. The menopause transition could be considered a window of vulnerability; however, it is also a window of opportunity for intervention. Thus, the menopause transition is a critical sensitive window whereby there is opportunity for turning points for healthy aging trajectories. Preclinical research can aid in this pursuit of scientific discovery for modifiable factors and treatments, and their particular parameters. Rodent menopause models include surgical and transitional variations, allowing detection of precise determinants impacting menopause-related outcomes. These models permit systematic manipulation of endogenous and exogenous hormone exposures across the lifespan, with infinite outcome measurements ranging from molecular to behavioral. This research is uniquely poised to address complex, interactive hypotheses with extensive control in a relatively short timeframe, including dissociation of age and menopause effects. To understand the many dynamic changes with menopause, iterative and reciprocal communication between clinical and preclinical domains of science is key.
女性中年期通常包括绝经过渡阶段，这是一个激素发生转变、适应和重新组织的时期。与这一动态的生理变化时期同时发生的是，存在一些可能可改变的因素，它们会影响疾病、短期和长期健康结果、症状出现以及寿命。绝经过渡阶段可被视为一个脆弱窗口；然而，它也是进行干预的机会窗口。因此，绝经过渡是一个关键的敏感窗口，在此存在使健康衰老轨迹出现转折点的机会。临床前研究有助于探索可改变因素、治疗方法及其特定参数的科学发现。啮齿动物绝经模型包括手术和过渡性变体，能够检测影响绝经相关结果的精确决定因素。这些模型允许在整个生命周期内系统地操纵内源性和外源性激素暴露，具有从分子到行为的无限结果测量。这项研究特别适合在相对较短的时间内通过广泛的控制来解决复杂的、相互作用的假设，包括区分年龄和绝经的影响。为了理解绝经带来的诸多动态变化，临床和临床前科学领域之间的迭代和相互交流是关键。
