Macedo Iara Tersia Freitas, Bevilaqua Claudia Maria Leal, de Oliveira Lorena Mayana Beserra, Camurça-Vasconcelos Ana Lourdes Fernandes, Vieira Luiz da Silva, Amóra Sthenia Dos Santos Albano
Laboratório de Doenças Parasitárias, Programa de Pós-Graduação em Ciências Veterinárias, Universidade Estadual do Ceará–UECE, Brazil.
Rev Bras Parasitol Vet. 2011 Jul-Sep;20(3):223-7. doi: 10.1590/s1984-29612011000300009.
Phytotherapy may be an alternative strategy for controlling gastrointestinal parasites. This study evaluated the anthelmintic efficacy of Eucalyptus citriodora essential oil (EcEO). The in vitro effects of EcEO were determined through testing the inhibition of egg hatching and larval development of Haemonchus contortus. EcEO was subjected to acute toxicity testing on mice, orally and intraperitoneally. The in vivo effects of EcEO were determined by the fecal egg count reduction test (FECRT) in goats infected with gastrointestinal nematodes. The results showed that 5.3 mg.mL(-1) EcEO inhibited egg hatching by 98.8% and 10.6 mg.mL(-1) EcEO inhibited H. contortus larval development by 99.71%. The lethal doses for 50% of the mice were 4153 and 622.8 mg.kg(-1), for acute toxicity orally and intraperitoneally. In the FECRT, the efficacy of EcEO and ivermectin was 66.25 and 79.16% respectively, on goat gastrointestinal nematodes eight days after treatment. EcEO showed in vitro and in vivo anthelmintic activity.
植物疗法可能是控制胃肠道寄生虫的一种替代策略。本研究评估了柠檬桉叶精油（EcEO）的驱虫效果。通过测试EcEO对捻转血矛线虫虫卵孵化和幼虫发育的抑制作用来确定其体外效果。对小鼠进行EcEO的口服和腹腔注射急性毒性试验。通过对感染胃肠道线虫的山羊进行粪便虫卵计数减少试验（FECRT）来确定EcEO的体内效果。结果表明，5.3 mg.mL(-1) 的EcEO可抑制98.8%的虫卵孵化，10.6 mg.mL(-1) 的EcEO可抑制99.71%的捻转血矛线虫幼虫发育。口服和腹腔注射急性毒性试验中，50%小鼠的致死剂量分别为4153和622.8 mg.kg(-1)。在FECRT中，治疗八天后，EcEO和伊维菌素对山羊胃肠道线虫的疗效分别为66.25%和79.16%。EcEO在体外和体内均表现出驱虫活性。
