通过分子识别在结晶分子瓶中进行 Diels-Alder 反应。

Diels-Alder via molecular recognition in a crystalline molecular flask.

机构信息

Department of Applied Chemistry, School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8656, Japan.

出版信息

J Am Chem Soc. 2011 Oct 26;133(42):16806-8. doi: 10.1021/ja2079064. Epub 2011 Oct 5.

DOI:10.1021/ja2079064

PMID:21961877

Abstract

In the pore of a porous coordination network, Diels-Alder reactants, a diene and a dienophile, are recognized by donor-acceptor and multiple H-bond interactions, respectively, and fixed at ideal positions for the reaction. Heating the crystals promoted the Diels-Alder reactions with enhanced reactivity and controlled regioselectivity as clearly monitored by in situ X-ray crystallography.

摘要

在多孔配位网络的孔道中，Diels-Alder 反应物（双烯和亲双烯体）分别通过供体-受体和多个氢键相互作用被识别，并固定在反应的理想位置。加热晶体促进了 Diels-Alder 反应，反应活性增强，区域选择性得到控制，这可以通过原位 X 射线晶体学清楚地监测到。