Division of Reproductive Medicine, Department of Obstetrics and Gynaecology, VU University Medical Center, Amsterdam, the Netherlands.
Fertil Steril. 2011 Oct;96(4):985-90. doi: 10.1016/j.fertnstert.2011.07.1149.
To investigate whether having a Down syndrome pregnancy at a relatively young age is associated with lower ovarian reserve as reflected by lower antimüllerian hormone (AMH) levels and the occurrence of earlier menopause.
Retrospective, case control study.
Not applicable.
PATIENT(S): Two hundred twenty mothers (118 trisomy cases, 102 controls).
INTERVENTION(S): Questionnaire and serum AMH measurement.
MAIN OUTCOME MEASURE(S): Serum AMH levels and menopause, defined as not having a menstrual cycle for at least 1 year.
RESULT(S): The participant response rate was 93%. After applying the exclusion criteria, 144 women were evaluable (73 trisomy cases, and 71 controls). The baseline characteristics of the women were not statistically significantly different. More women with a Down syndrome pregnancy had an AMH level below 0.5 μg/L, a difference that was statistically significant. Eleven women (15.1%) in the Down syndrome group had reached menopause compared with 9 (12.7%) of the controls.
CONCLUSION(S): Women who have had a Down syndrome pregnancy at a younger age show signs of limited ovarian reserve, as evidenced by their frequently having lower AMH levels. The study has found no obvious signs of early menopause thus far. Whether their age at menopause is within the normal range remains to be determined.
探究较年轻时怀有唐氏综合征妊娠是否与较低的卵巢储备功能相关，这种储备功能可通过较低的抗苗勒管激素（AMH）水平和更早绝经来反映。
回顾性病例对照研究。
不适用。
220 位母亲（118 例唐氏综合征病例，102 例对照）。
问卷调查和血清 AMH 测量。
血清 AMH 水平和绝经，定义为至少 1 年没有月经周期。
参与者的回复率为 93%。应用排除标准后，144 位女性可进行评估（73 例唐氏综合征病例，71 例对照）。女性的基线特征无统计学显著差异。更多唐氏综合征妊娠的女性 AMH 水平低于 0.5μg/L，差异有统计学意义。唐氏综合征组中有 11 位女性（15.1%）已绝经，而对照组中有 9 位女性（12.7%）。
较年轻时怀有唐氏综合征妊娠的女性表现出卵巢储备有限的迹象，这表现为她们的 AMH 水平常常较低。目前尚未发现明显的早绝经迹象。她们的绝经年龄是否在正常范围内仍有待确定。
