Division of Emergency Medicine, Stanford University Medical Center, Stanford, California, USA.
High Alt Med Biol. 2011 Fall;12(3):223-7. doi: 10.1089/ham.2010.1101.
We performed this study to determine the prevalence of elevated D-dimer, a marker for deep venous thrombosis (DVT), in asymptomatic high altitude climbers. On-site personnel enrolled a convenience sample of climbers at Mt. Everest Base Camp (Nepal), elevation 5340 m (17,500 ft), during a single spring climbing season. Subjects were enrolled after descent to base camp from higher elevation. The subjects completed a questionnaire to evaluate their risk factors for DVT. We then performed a D-dimer test in asymptomatic individuals. If the D-dimer test was negative, DVT was considered ruled out. Ultrasound was available to perform lower-extremity compression ultrasounds to evaluate for DVT in case the D-dimer was positive. We enrolled 76 high altitude climbers. None had a positive D-dimer test. The absence of positive D-dimer tests suggests a low prevalence of DVT in asymptomatic high altitude climbers.
我们进行这项研究旨在确定无症状高海拔登山者中深静脉血栓形成（DVT）标志物 D-二聚体升高的患病率。现场人员在尼泊尔珠穆朗玛峰大本营（海拔 5340 米，17500 英尺）的一个春季登山季期间，对登山者进行了方便抽样。在从高海拔地区下降到大本营后，受试者被纳入研究。受试者完成了一份问卷，以评估他们患 DVT 的风险因素。然后，我们对无症状个体进行 D-二聚体检测。如果 D-二聚体检测为阴性，则认为排除 DVT。如果 D-二聚体阳性，则可进行下肢加压超声检查以评估 DVT。我们共纳入了 76 名高海拔登山者。他们的 D-二聚体检测均为阴性。没有阳性 D-二聚体检测结果表明无症状高海拔登山者中 DVT 的患病率较低。
