Asthma & Allergy Research Unit, Centre for Cardiovascular & Lung Biology, Ninewells Hospital & Medical School, University of Dundee, Scotland, UK.
Ann Allergy Asthma Immunol. 2011 Oct;107(4):317-22. doi: 10.1016/j.anai.2011.07.011.
Impulse oscillometry (IOS) is an effort-independent and patient-friendly pulmonary function technique, but limited data are available that correlate the bronchodilator response using spirometry and IOS in adult asthmatic and healthy subjects.
To compare spirometry and IOS in ongoing bronchodilator response.
The study was a prospective evaluation of patients with asthma and healthy subjects attending screening at a research unit in a university teaching hospital. Reversibility testing was carried out using standardized American Thoracic Society/European Respiratory Society (ATS/ERS) criteria after administering 400 μg salbutamol by AccuhalerTM. Impulse oscillometry measurements (resistance at 5 Hz [R5], resistance at 20 Hz [R20], reactance at 5 Hz [X5]) and spirometry (forced expiratory volume in 1 second [FEV(1)], forced vital capacity [FVC], forced expiratory flow from 25% to 75% of vital capacity [FEF(25-75)]) were recorded pre and postbronchodilator.
Ninety-five asthmatic and 61 healthy subjects underwent screening. Mean percent (standard error of the mean [SEM]) baseline prebronchodilator FEV(1) was 83.99 (2.23) for patients with asthma, and 99.25 (1.72) for healthy subjects. Baseline percent predicted IOS indices in the group with asthma were 162.22 (7.5) for R5; 154.73 (4.71) for R20; and 441.72 (173.86) for X5. In healthy volunteers, corresponding values were 111.01 (3.96), 127.75 (4.12), and -229.80 (125.75). R5 was the only IOS measure that showed correlation with spirometry (FEV(1)) in both groups. The mean percent (SEM) predicted postbronchodilator change in FEV(1) and R5 in patients with asthma was 6.35 (0.65) and -33.78 (4.43); correspondingly in healthy subjects it was 2.24 (0.32) and -14.91 (2.48). A negative correlation was demonstrated (r = -0.40, P < .001 between the 2 indices in patients with asthma. Linear regression modeling demonstrated that 1 unit change in %FEV(1) corresponds to a 2.5% change in %R5.
Low-frequency IOS as R5 and spirometry as FEV(1) correlate in patients with asthma and healthy subjects, with changes that can be predicted by linear regression.
脉冲振荡法（IOS）是一种不依赖于努力且对患者友好的肺功能技术，但在哮喘患者和健康受试者中，关于使用 IOS 与 spirometry 来评估支气管扩张剂反应的相关性的数据有限。
比较 IOS 与 spirometry 在持续支气管扩张剂反应中的应用。
这是一项在一所大学教学医院的研究单位进行的哮喘患者和健康受试者筛查的前瞻性评估。在使用 AccuhalerTM 给予 400μg沙丁胺醇后，根据美国胸科学会/欧洲呼吸学会（ATS/ERS）的标准进行了可变性测试。在支气管扩张剂治疗前后，分别记录脉冲振荡测量（5Hz 时的阻力[R5]、20Hz 时的阻力[R20]、5Hz 时的电抗[X5]）和 spirometry（用力呼气 1 秒量[FEV(1)]、用力肺活量[FVC]、从 25%到 75%肺活量时的强制呼气流速[FEF(25-75)])。
95 名哮喘患者和 61 名健康受试者接受了筛查。哮喘患者支气管扩张剂治疗前平均（标准误差[SEM]）FEV(1)的百分比为 83.99（2.23），健康受试者为 99.25（1.72）。哮喘组支气管扩张剂治疗前 IOS 指数的百分比预测值分别为 R5：162.22（7.5）；R20：154.73（4.71）；X5：441.72（173.86）。在健康志愿者中，相应的值分别为 111.01（3.96）、127.75（4.12）和-229.80（125.75）。在两组中，R5 是唯一与 spirometry（FEV(1)）相关的 IOS 测量值。哮喘患者支气管扩张剂治疗后 FEV(1)和 R5 的平均（SEM）百分比预测变化分别为 6.35（0.65）和-33.78（4.43）；健康受试者分别为 2.24（0.32）和-14.91（2.48）。在哮喘患者中，两种指标之间存在负相关性（r=-0.40，P<0.001）。线性回归模型表明，FEV(1)的 1 个单位变化对应于 R5 的 2.5%变化。
哮喘患者和健康受试者中低频 IOS（以 R5 表示）和 spirometry（以 FEV(1)表示）呈相关性，其变化可以通过线性回归进行预测。
