Mirmohammadi Seyyed Jalil, Dehghan Dehnavi Alireza, Vakili Mahmood, Davari Mohammad Hossein, Mehrparvar Amir Houshang, Zare Sakhvidi Mohammad Javad
Industrial Diseases Research Center, Department of Occupational Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Department of Occupational Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Tanaffos. 2024 Mar;23(3):287-293.
Fractional exhaled nitric oxide is a method of assessing inflammation in the airway and its level may affected by some factors such as age, gender, and body mass index. This study was performed to assess the relationship between "Body Mass Index" (BMI) and FeNO.
This was a cross-sectional study on 879 adult subjects participating in the Shahedieh Cohort Study. BMI and FeNO were measured for each participant. Participants were divided into five BMI groups: underweight, normal, overweight, obese, and morbid obese FeNo level was compared between groups. The data were analyzed by SPSS (ver. 20) using Kolmogorov-Smirnov, Kruskal-Wallis, Mann-Whitney U tests, Spearman's correlation, and multivariate logistic regression tests.
The mean FeNO in all participants was 7.87±8.28 ppb. There was a significant positive correlation between age and FeNO. FeNO was declined by increasing BMI, so the highest FeNO was observed in underweight and the lowest FeNO was observed in morbid obese individuals. However, there was not a significant difference in FeNO level between different BMI categories (P =0.28). The mean FeNO level was significantly correlated to BMI only in participants younger than 48 years.
The results of this study showed that BMI is probably negatively correlated with FeNO level in middle-aged people younger than 48 years, but not in older people.
呼出一氧化氮分数是评估气道炎症的一种方法，其水平可能受年龄、性别和体重指数等一些因素的影响。本研究旨在评估“体重指数”（BMI）与呼出一氧化氮分数（FeNO）之间的关系。
这是一项对879名参与沙赫迪耶队列研究的成年受试者进行的横断面研究。测量了每位参与者的BMI和FeNO。参与者被分为五个BMI组：体重过轻、正常、超重、肥胖和病态肥胖。比较了各组之间的FeNO水平。使用SPSS（版本20）通过Kolmogorov-Smirnov检验、Kruskal-Wallis检验、Mann-Whitney U检验、Spearman相关性检验和多因素逻辑回归检验对数据进行分析。
所有参与者的平均FeNO为7.87±8.28 ppb。年龄与FeNO之间存在显著正相关。FeNO随着BMI的增加而下降，因此在体重过轻的个体中观察到最高的FeNO，在病态肥胖的个体中观察到最低的FeNO。然而，不同BMI类别之间的FeNO水平没有显著差异（P = 0.28）。仅在年龄小于48岁的参与者中，平均FeNO水平与BMI显著相关。
本研究结果表明，BMI可能与48岁以下中年人的FeNO水平呈负相关，但与老年人无关。
