多效信号通路调控酵母发育。
Pleiotropic signaling pathways orchestrate yeast development.
机构信息
Department of Biology and IGSP Center for Systems Biology, Duke University, Box 90338, Durham, NC 27708, USA.
出版信息
Curr Opin Microbiol. 2011 Dec;14(6):676-81. doi: 10.1016/j.mib.2011.09.004. Epub 2011 Sep 28.
Abstract
Developmental phenotypes in Saccharomyces cerevisiae and related yeasts include responses such as filamentous growth, sporulation, and the formation of biofilms and complex colonies. These developmental phenotypes are regulated by evolutionarily conserved, nutrient-responsive signaling networks. The signaling mechanisms that control development in yeast are highly pleiotropic--all the known pathways contribute to the regulation of multiple developmental outcomes. This degree of pleiotropy implies that perturbations of these signaling pathways, whether genetic, biochemical, or environmentally induced, can manifest in multiple (and sometimes unexpected) ways. We summarize the current state of knowledge of developmental pleiotropy in yeast and discuss its implications for understanding functional relationships.
摘要
酿酒酵母和相关酵母的发育表型包括丝状生长、孢子形成以及生物膜和复杂菌落的形成等反应。这些发育表型受进化上保守的、营养响应的信号网络调控。控制酵母发育的信号机制具有高度的多效性——所有已知的途径都有助于调节多种发育结果。这种多效性意味着这些信号通路的干扰，无论是遗传的、生化的还是环境诱导的，都可能以多种（有时是意想不到的）方式表现出来。我们总结了酵母中发育多效性的现有知识状态，并讨论了其对理解功能关系的意义。
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