Department of Pathology, Faculty of Veterinary Medicine, USAMV, Calea Mănăştur 3-5, Cluj-Napoca 400372, Romania.
Vet J. 2012 Jun;192(3):449-54. doi: 10.1016/j.tvjl.2011.08.029. Epub 2011 Oct 1.
This study assesses the impact of equine infectious anaemia virus (EIAV) infection on the oxidant/antioxidant equilibrium of horses. Blood samples from 96 Romanian horses aged 1-25 years, were divided into different groups according to their EIAV-infection status, age, and time post-seroconversion. The effect of infection on oxidative stress was estimated by measuring enzymatic antioxidants (superoxide dismutase [SOD], glutathione peroxidase [GPx] and catalase), non-enzymatic antioxidants (uric acid and carotenoids), and lipid peroxidation (malondialdehyde [MDA]). Infection modified the oxidant/antioxidant equilibrium in the horses, influencing GPx and uric acid levels (P<0.05). Time post-seroconversion also contributed to oxidative stress imbalance, exhibiting a significant influence on both SOD and MDA concentrations in the blood (P<0.05). Animal age did not have a significant influence on oxidative stress. Recently infected horses (<1 year following seroconversion), and horses >5 years old, represented the most vulnerable category in terms of oxidative stress, followed by recently infected animals <5 years old. The results of this study are novel in implicating EIAV infection in the development of oxidative stress in horses.
本研究评估了马传染性贫血病毒（EIAV）感染对马氧化/抗氧化平衡的影响。从 96 匹 1-25 岁的罗马尼亚马的血液样本中，根据 EIAV 感染状况、年龄和血清转化后时间，将其分为不同组。通过测量酶抗氧化剂（超氧化物歧化酶[SOD]、谷胱甘肽过氧化物酶[GPx]和过氧化氢酶）、非酶抗氧化剂（尿酸和类胡萝卜素）和脂质过氧化（丙二醛[MDA]）来评估感染对氧化应激的影响。感染改变了马的氧化/抗氧化平衡，影响了 GPx 和尿酸水平（P<0.05）。血清转化后时间也导致氧化应激失衡，对血液中 SOD 和 MDA 浓度有显著影响（P<0.05）。动物年龄对氧化应激没有显著影响。最近感染（血清转化后<1 年）和>5 岁的马是氧化应激最脆弱的类别，其次是最近感染的<5 岁马。本研究结果表明，EIAV 感染可导致马发生氧化应激，这是一个新颖的发现。
