Department of Family Medicine, Sahmyook Medical Center, Seoul, South Korea.
Urology. 2012 Jan;79(1):182-7. doi: 10.1016/j.urology.2011.08.011. Epub 2011 Oct 2.
To understand the relationship between lower urinary tract symptoms (LUTS) and renal function by prostate volume (PV) in Korean men. LUTS can be related to early renal dysfunction, irrespective of bladder outlet obstructive lesions, few studies have been conducted.
We conducted a cross-sectional survey of 3713 men, aged≥40 years, who received routine comprehensive health evaluations, including transrectal ultrasonography and the International Prostate Symptom Score questionnaire. We used the estimated glomerular filtration rate (GFR) for the assessment of renal function and the IPSS for LUTS severity. We compared LUTS and GFR using multivariate regression analysis after adjusting for age and/or PV.
An increasing severity of LUTS, especially voiding LUTS, was associated with a decreasing GFR in the older age group (≥55 years). In a stratified analysis by PV of 30 cm3, voiding LUTS showed a negative association with GFR, irrespective of the PV (P for trend<.01 and P for trend<.02), but total LUTS did so only in the small PV group.
In men without known urinary tract disease, LUTS and renal function had a negative association, especially in older men with a normal PV. Although the underlying mechanism is uncertain, physicians who treat patients with moderate or severe LUTS should monitor renal function, even in patients with a normal PV.
通过前列腺体积（PV）了解韩国男性下尿路症状（LUTS）与肾功能之间的关系。LUTS 可能与早期肾功能障碍有关，而与膀胱出口梗阻性病变无关，尽管进行了一些研究。
我们对 3713 名年龄≥40 岁的男性进行了横断面调查，他们接受了常规的全面健康评估，包括经直肠超声检查和国际前列腺症状评分问卷。我们使用估算的肾小球滤过率（GFR）评估肾功能，使用 IPSS 评估 LUTS 严重程度。我们调整了年龄和/或 PV 后，使用多变量回归分析比较了 LUTS 和 GFR。
在年龄较大（≥55 岁）的人群中，随着 LUTS 严重程度的增加，尤其是排尿 LUTS，GFR 逐渐降低。在按 30 cm3 划分的 PV 分层分析中，无论 PV 如何，排尿 LUTS 与 GFR 呈负相关（趋势 P<.01 和趋势 P<.02），但总 LUTS 仅在小 PV 组中呈负相关。
在没有已知尿路疾病的男性中，LUTS 和肾功能呈负相关，尤其是在 PV 正常的老年男性中。尽管潜在机制尚不清楚，但治疗中重度 LUTS 患者的医生应监测肾功能，即使在 PV 正常的患者中也是如此。
