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本文引用的文献

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γ-AApeptides bind to RNA by mimicking RNA-binding proteins.γ-AA 肽通过模拟 RNA 结合蛋白与 RNA 结合。
Org Biomol Chem. 2011 Oct 7;9(19):6604-9. doi: 10.1039/c1ob05738c. Epub 2011 Aug 8.
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Non-hemolytic α-AApeptides as antimicrobial peptidomimetics.非溶血性 α-AA 肽作为抗菌肽模拟物。
Chem Commun (Camb). 2011 Sep 14;47(34):9729-31. doi: 10.1039/c1cc13684d. Epub 2011 Jul 21.
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Role of the conformational rigidity in the design of biomimetic antimicrobial compounds.构象刚性在仿生抗菌化合物设计中的作用。
Angew Chem Int Ed Engl. 2010 Nov 2;49(45):8462-5. doi: 10.1002/anie.201003104.
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Antibacterial activities of short designer peptides: a link between propensity for nanostructuring and capacity for membrane destabilization.短肽设计物的抗菌活性：纳米结构倾向与膜破坏能力之间的联系。
Biomacromolecules. 2010 Feb 8;11(2):402-11. doi: 10.1021/bm901130u.
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De novo design of antimicrobial polymers, foldamers, and small molecules: from discovery to practical applications.从头设计抗菌聚合物、类肽和小分子：从发现到实际应用。
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De novo design and in vivo activity of conformationally restrained antimicrobial arylamide foldamers.构象受限抗菌芳基酰胺折叠体的从头设计与体内活性
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Structure-function relationships in peptoids: recent advances toward deciphering the structural requirements for biological function.类肽中的结构-功能关系：解析生物学功能结构要求的最新进展
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De novo designed synthetic mimics of antimicrobial peptides.抗菌肽的从头设计合成模拟物。
Curr Opin Biotechnol. 2008 Dec;19(6):620-7. doi: 10.1016/j.copbio.2008.10.013. Epub 2008 Nov 17.
9
Peptoids that mimic the structure, function, and mechanism of helical antimicrobial peptides.模拟螺旋抗菌肽结构、功能及作用机制的类肽。
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Mimicry of antimicrobial host-defense peptides by random copolymers.随机共聚物对抗菌宿主防御肽的模拟
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鉴定具有强效广谱抗菌活性的 γ-AApeptides。

Identification of γ-AApeptides with potent and broad-spectrum antimicrobial activity.

机构信息

Department of Chemistry, University of South Florida, 4202 E. Fowler Ave, Tampa, FL 33620, USA.

Department of Cell Biology, Microbiology and Molecular Biology, 4202 E. Fowler Ave, Tampa, FL 33620, USA.

出版信息

Chem Commun (Camb). 2011 Nov 28;47(44):12197-12199. doi: 10.1039/c1cc14476f. Epub 2011 Oct 3.

DOI:10.1039/c1cc14476f
PMID:21963627
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3746764/
Abstract

We report the identification of a new class of antimicrobial peptidomimetics-γ-AApeptides with potent and broad-spectrum activity, including clinically-relevant strains that are unresponsive to most antibiotics. They are also not prone to select for drug-resistance.

摘要

我们报告了一类新型的抗菌肽模拟物——γ-AA 肽，它们具有强大而广谱的活性，包括对大多数抗生素无反应的临床相关菌株。它们也不容易产生耐药性。