Nishida Yuichiro, Iyadomi Minako, Higaki Yasuki, Tanaka Hiroaki, Hara Megumi, Tanaka Keitaro
Department of Preventive Medicine, Faculty of Medicine, Saga University, Japan.
Intern Med. 2011;50(19):2121-8. doi: 10.2169/internalmedicine.50.5506. Epub 2011 Oct 1.
Physical activity (PA) is considered an important approach to prevent and treat obesity and hyperuricemia. The purpose of the present study was to examine the influence of PA intensity and aerobic fitness on anthropometric indices and serum uric acid in obese individuals.
PA was examined using a single-axial accelerometer and aerobic fitness was assessed by electric cycle ergometry in obese middle-aged men (n=71, 47.2 ± 4.4 years). PA was defined as light (<3 metabolic equivalents [METs]), moderate (3.0-6.0 METs) or vigorous (>6.0 METs) intensity from the corresponding METs multiplied by time spent at the corresponding intensity levels. Serum uric acid was measured by the uricase peroxidase method.
The association between aerobic fitness index (lactate threshold) and serum uric acid did not reach statistical significance after adjustment for potential confounding factors (age, body mass index [BMI], and alcohol consumption) (β=-0.110, p=0.138). Light intensity PA was inversely associated with BMI and waist circumference, even after adjustment for age and alcohol consumption (BMI: β=-0.543, p=0.023; waist circumference: β=-1.333, p=0.016). Moderate intensity PA, but not light or vigorous intensity PA, was inversely correlated with the uric acid level and this remained significant after adjustment for age, BMI, and alcohol consumption (β=-0.222, p=0.036).
Our results suggest that light intensity PA may have an important role in weight control while moderate intensity PA may be associated with the lower uric acid concentrations in obese individuals.
体育活动（PA）被认为是预防和治疗肥胖及高尿酸血症的重要方法。本研究的目的是探讨PA强度和有氧适能对肥胖个体人体测量指标和血清尿酸的影响。
使用单轴加速度计检测PA，并通过电动自行车测力计评估肥胖中年男性（n = 71，47.2±4.4岁）的有氧适能。PA根据相应的代谢当量（METs）乘以在相应强度水平下花费的时间定义为轻度（<3代谢当量[METs]）、中度（3.0 - 6.0 METs）或剧烈（>6.0 METs）强度。采用尿酸酶过氧化物酶法测定血清尿酸。
在调整潜在混杂因素（年龄、体重指数[BMI]和饮酒量）后，有氧适能指数（乳酸阈）与血清尿酸之间的关联未达到统计学意义（β = -0.110，p = 0.138）。即使在调整年龄和饮酒量后，轻度强度PA与BMI和腰围呈负相关（BMI：β = -0.543，p = 0.023；腰围：β = -1.333，p = 0.016）。中度强度PA而非轻度或剧烈强度PA与尿酸水平呈负相关，在调整年龄、BMI和饮酒量后仍具有显著性（β = -0.222，p = 0.036）。
我们的结果表明，轻度强度PA可能在体重控制中起重要作用，而中度强度PA可能与肥胖个体较低的尿酸浓度有关。
