口腔疾病与痴呆和认知能力下降的未来风险有关：基于糖尿病和血管疾病行动：培哚普利氨氯地平与贝那普利（ADVANCE）试验的前瞻性队列研究。
Oral disease in relation to future risk of dementia and cognitive decline: prospective cohort study based on the Action in Diabetes and Vascular Disease: Preterax and Diamicron Modified-Release Controlled Evaluation (ADVANCE) trial.
机构信息
Department of Epidemiology and Public Health, University College of London, Torrington Place, London, UK.
出版信息
Eur Psychiatry. 2013 Jan;28(1):49-52. doi: 10.1016/j.eurpsy.2011.07.005. Epub 2011 Oct 2.
Abstract
OBJECTIVE
Examine the association of oral disease with future dementia/cognitive decline in a cohort of people with type 2 diabetes.
METHODS
A total of 11,140 men and women aged 55-88 years at study induction with type 2 diabetes participated in a baseline medical examination when they reported the number of natural teeth and days of bleeding gums. Dementia and cognitive decline were ascertained periodically during a 5-year follow-up.
RESULTS
Relative to the group with the greatest number of teeth (more than or equal to 22), having no teeth was associated with the highest risk of both dementia (hazard ratio; 95% confidence interval: 1.48; 1.24, 1.78) and cognitive decline (1.39; 1.21, 1.59). Number of days of bleeding gums was unrelated to these outcomes.
CONCLUSIONS
Tooth loss was associated with an increased risk of both dementia and cognitive decline.
摘要
目的
在 2 型糖尿病患者队列中，研究口腔疾病与未来痴呆/认知能力下降的关系。
方法
共有 11140 名年龄在 55-88 岁的男性和女性在研究开始时患有 2 型糖尿病，他们在基线体检时报告了天然牙齿的数量和牙龈出血的天数。在 5 年的随访期间，定期确定痴呆和认知能力下降的情况。
结果
与牙齿数量最多（大于或等于 22 颗）的组相比，无牙与痴呆（风险比；95%置信区间：1.48；1.24，1.78）和认知能力下降（1.39；1.21，1.59）的风险最高相关。牙龈出血天数与这些结果无关。
结论
牙齿缺失与痴呆和认知能力下降的风险增加有关。
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