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本文引用的文献

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Relationship of tooth loss to mild memory impairment and cognitive impairment: findings from the Fujiwara-kyo study.牙齿缺失与轻度记忆障碍和认知障碍的关系：来自 Fujiwara-kyo 研究的结果。
Behav Brain Funct. 2010 Dec 31;6:77. doi: 10.1186/1744-9081-6-77.
2
Oral disease and subsequent cardiovascular disease in people with type 2 diabetes: a prospective cohort study based on the Action in Diabetes and Vascular Disease: Preterax and Diamicron Modified-Release Controlled Evaluation (ADVANCE) trial.2 型糖尿病患者的口腔疾病与随后发生的心血管疾病：基于糖尿病和血管疾病行动：培哚普利氨氯地平与贝那普利叶酸钙（ADVANCE）试验的前瞻性队列研究。
Diabetologia. 2010 Nov;53(11):2320-7. doi: 10.1007/s00125-010-1862-1. Epub 2010 Aug 11.
3
Tooth loss, apolipoprotein E, and decline in delayed word recall.牙齿缺失、载脂蛋白 E 与延迟词语回忆能力下降。
J Dent Res. 2010 May;89(5):473-7. doi: 10.1177/0022034509357881. Epub 2010 Feb 5.
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TNF-alpha and antibodies to periodontal bacteria discriminate between Alzheimer's disease patients and normal subjects.肿瘤坏死因子-α和牙周细菌抗体可区分阿尔茨海默病患者和正常受试者。
J Neuroimmunol. 2009 Nov 30;216(1-2):92-7. doi: 10.1016/j.jneuroim.2009.08.013. Epub 2009 Sep 19.
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Potentially modifiable risk factors for dementia in identical twins.同卵双胞胎中痴呆症潜在的可改变风险因素。
Alzheimers Dement. 2006 Apr;2(2):110-7. doi: 10.1016/j.jalz.2006.01.002.
6
Periodontitis is associated with cognitive impairment among older adults: analysis of NHANES-III.牙周炎与老年人认知障碍有关：美国国家健康和营养检查调查III（NHANES-III）分析。
J Neurol Neurosurg Psychiatry. 2009 Nov;80(11):1206-11. doi: 10.1136/jnnp.2009.174029. Epub 2009 May 5.
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Inflammation as a potential mediator for the association between periodontal disease and Alzheimer's disease.炎症作为牙周病与阿尔茨海默病之间关联的潜在介质。
Neuropsychiatr Dis Treat. 2008 Oct;4(5):865-76. doi: 10.2147/ndt.s3610.
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The relationship between type 2 diabetes and dementia.2型糖尿病与痴呆症之间的关系。
Br Med Bull. 2008;88(1):131-46. doi: 10.1093/bmb/ldn042. Epub 2008 Nov 23.
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The relationship between oral health and diabetes mellitus.口腔健康与糖尿病之间的关系。
J Am Dent Assoc. 2008 Oct;139 Suppl:19S-24S. doi: 10.14219/jada.archive.2008.0363.
10
Tooth loss, systemic inflammation, and prevalent stroke among participants in the reasons for geographic and racial difference in stroke (REGARDS) study.卒中地理和种族差异原因（REGARDS）研究参与者中的牙齿脱落、全身炎症与中风患病率
Atherosclerosis. 2009 Apr;203(2):615-9. doi: 10.1016/j.atherosclerosis.2008.07.037. Epub 2008 Aug 8.

口腔疾病与痴呆和认知能力下降的未来风险有关：基于糖尿病和血管疾病行动：培哚普利氨氯地平与贝那普利（ADVANCE）试验的前瞻性队列研究。

Oral disease in relation to future risk of dementia and cognitive decline: prospective cohort study based on the Action in Diabetes and Vascular Disease: Preterax and Diamicron Modified-Release Controlled Evaluation (ADVANCE) trial.

机构信息

Department of Epidemiology and Public Health, University College of London, Torrington Place, London, UK.

出版信息

Eur Psychiatry. 2013 Jan;28(1):49-52. doi: 10.1016/j.eurpsy.2011.07.005. Epub 2011 Oct 2.

DOI:10.1016/j.eurpsy.2011.07.005
PMID:21964484
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4170753/
Abstract

OBJECTIVE

Examine the association of oral disease with future dementia/cognitive decline in a cohort of people with type 2 diabetes.

METHODS

A total of 11,140 men and women aged 55-88 years at study induction with type 2 diabetes participated in a baseline medical examination when they reported the number of natural teeth and days of bleeding gums. Dementia and cognitive decline were ascertained periodically during a 5-year follow-up.

RESULTS

Relative to the group with the greatest number of teeth (more than or equal to 22), having no teeth was associated with the highest risk of both dementia (hazard ratio; 95% confidence interval: 1.48; 1.24, 1.78) and cognitive decline (1.39; 1.21, 1.59). Number of days of bleeding gums was unrelated to these outcomes.

CONCLUSIONS

Tooth loss was associated with an increased risk of both dementia and cognitive decline.

摘要

目的

在 2 型糖尿病患者队列中，研究口腔疾病与未来痴呆/认知能力下降的关系。

方法

共有 11140 名年龄在 55-88 岁的男性和女性在研究开始时患有 2 型糖尿病，他们在基线体检时报告了天然牙齿的数量和牙龈出血的天数。在 5 年的随访期间，定期确定痴呆和认知能力下降的情况。

结果

与牙齿数量最多（大于或等于 22 颗）的组相比，无牙与痴呆（风险比；95%置信区间：1.48；1.24，1.78）和认知能力下降（1.39；1.21，1.59）的风险最高相关。牙龈出血天数与这些结果无关。

结论

牙齿缺失与痴呆和认知能力下降的风险增加有关。