School of Psychology, Cardiff University, 70 Park Place, Cardiff, CF10 3AT, Wales, UK.
Neurosci Biobehav Rev. 2012 Aug;36(7):1579-96. doi: 10.1016/j.neubiorev.2011.09.005. Epub 2011 Sep 24.
A review of medial temporal lobe connections reveals three distinct groupings of hippocampal efferents. These efferent systems and their putative memory functions are: (1) The 'extended-hippocampal system' for episodic memory, which involves the anterior thalamic nuclei, mammillary bodies and retrosplenial cortex, originates in the subicular cortices, and has a largely laminar organisation; (2) The 'rostral hippocampal system' for affective and social learning, which involves prefrontal cortex, amygdala and nucleus accumbens, has a columnar organisation, and originates from rostral CA1 and subiculum; (3) The 'reciprocal hippocampal-parahippocampal system' for sensory processing and integration, which originates from the length of CA1 and the subiculum, and is characterised by columnar, connections with reciprocal topographies. A fourth system, the 'parahippocampal-prefrontal system' that supports familiarity signalling and retrieval processing, has more widespread prefrontal connections than those of the hippocampus, along with different thalamic inputs. Despite many interactions between these four systems, they may retain different roles in memory which when combined explain the importance of the medial temporal lobe for the formation of declarative memories.
内侧颞叶连接的综述揭示了海马体传出纤维的三个不同分组。这些传出系统及其假定的记忆功能为：（1）用于情景记忆的“扩展海马体系统”，涉及前丘脑核、乳头体和后扣带回皮质，起源于侧副皮质，具有广泛的层状组织；（2）用于情感和社会学习的“海马体前支系统”，涉及前额叶皮质、杏仁核和伏隔核，具有柱状组织，起源于前 CA1 和侧副皮质；（3）用于感觉处理和整合的“海马体-旁海马体系统”，起源于 CA1 和侧副皮质的全长，其特征是与相互拓扑的柱状连接；（4）“旁海马体-前额叶系统”支持熟悉信号和检索处理，其与海马体相比具有更广泛的前额叶连接，以及不同的丘脑输入。尽管这四个系统之间存在许多相互作用，但它们在记忆中可能保留着不同的作用，当它们结合在一起时，可以解释内侧颞叶对陈述性记忆形成的重要性。
