Safranski David L, Crabtree Jacob C, Huq Yameen R, Gall Ken
MedShape Solutions, 1575 Northside Drive NW Ste 440, Atlanta, GA, 30318.
Polymer (Guildf). 2011 Sep 29;52(21):4920-4927. doi: 10.1016/j.polymer.2011.08.033.
Poly(β-amino ester) networks are being explored for biomedical applications, but they may lack the mechanical properties necessary for long term implantation. The objective of this study is to evaluate the effect of adding methyl methacrylate on networks' mechanical properties under simulated physiological conditions. The networks were synthesized in two parts: (1) a biodegradable crosslinker was formed from a diacrylate and amine, (2) and then varying concentrations of methyl methacrylate were added prior to photopolymerizing the network. Degradation rate, mechanical properties, and glass transition temperature were studied as a function of methyl methacrylate composition. The crosslinking density played a limited role on mechanical properties for these networks, but increasing methyl methacrylate concentration improved the toughness by several orders of magnitude. Under simulated physiological conditions, networks showed increasing toughness or sustained toughness as degradation occurred. This work establishes a method of creating degradable networks with tailorable toughness while undergoing partial degradation.
聚（β-氨基酯）网络正被用于生物医学应用的探索，但它们可能缺乏长期植入所需的机械性能。本研究的目的是评估在模拟生理条件下添加甲基丙烯酸甲酯对网络机械性能的影响。网络分两步合成：（1）由二丙烯酸酯和胺形成可生物降解的交联剂，（2）然后在光聚合网络之前添加不同浓度的甲基丙烯酸甲酯。研究了降解速率、机械性能和玻璃化转变温度作为甲基丙烯酸甲酯组成的函数。交联密度对这些网络的机械性能作用有限，但增加甲基丙烯酸甲酯浓度可将韧性提高几个数量级。在模拟生理条件下，随着降解的发生，网络显示出韧性增加或韧性持续。这项工作建立了一种在部分降解时创建具有可定制韧性的可降解网络的方法。
