Smith Kathryn E, Sawicki Suzanne, Hyjek Michelle A, Downey Sara, Gall Ken
George C. Woodruff School of Mechanical Engineering, Georgia Institute of Technology, 771 Ferst Drive, Atlanta, GA 30332.
Polymer (Guildf). 2009 Oct 9;50(21):5112-5123. doi: 10.1016/j.polymer.2009.08.040.
The purpose of this study is to evaluate how the toughness of photopolymerizable (meth)acrylate networks is influenced by physiological conditions. By utilizing two ternary (meth)acrylate networks, MA-co-MMA-co-PEGDMA and 2HEMA-co-BMA-co-PEGDMA, relationships between glass transition temperature (T(g)), water content and state, and toughness were studied by varying the weight ratio of the linear monomers (MA to MMA or 2HEMA to BMA). Differential scanning calorimetry and thermogravimetric analysis were performed to evaluate the thermal behavior and water content as a function of either MA or 2HEMA concentration while tensile strain-to-failure tests were performed at 37°C to determine network toughness. Both networks exhibited a maximum in toughness in PBS in the composition corresponding to a T(g) close to the testing temperature. This toughness maximum was achieved by adjusting the glass transition temperature and/or hydrophilicity through changes in chemistry. These relationships may be utilized to design tough photopolymerizable networks for use in mechanically rigorous biomedical applications.
本研究的目的是评估生理条件如何影响可光聚合的（甲基）丙烯酸酯网络的韧性。通过使用两种三元（甲基）丙烯酸酯网络，即MA-co-MMA-co-PEGDMA和2HEMA-co-BMA-co-PEGDMA，通过改变线性单体（MA与MMA或2HEMA与BMA）的重量比，研究了玻璃化转变温度（T(g)）、含水量和状态与韧性之间的关系。进行差示扫描量热法和热重分析以评估热行为和作为MA或2HEMA浓度函数的含水量，同时在37°C下进行拉伸断裂应变测试以确定网络韧性。在对应于接近测试温度的T(g)的组成中，两种网络在PBS中均表现出韧性最大值。通过改变化学组成来调节玻璃化转变温度和/或亲水性，从而实现了这种韧性最大值。这些关系可用于设计用于机械要求严格的生物医学应用的坚韧可光聚合网络。
