绣球丹参中的稀有碳骨架三萜类化合物：抗原生动物活性和绝对构型。

Triterpenoids with rare carbon skeletons from Salvia hydrangea: antiprotozoal activity and absolute configurations.

机构信息

Department of Phytochemistry, Medicinal Plants and Drugs Research Institute, Shahid Beheshti University, G. C., Evin, Tehran, Iran.

出版信息

J Nat Prod. 2011 Oct 28;74(10):2200-5. doi: 10.1021/np200559c. Epub 2011 Oct 3.

DOI:10.1021/np200559c

PMID:21967089

Abstract

Salvadione C (1) and perovskone B (2), two new triterpenoids with rare carbon skeletons, were isolated from an antiplasmodial n-hexane extract of Salvia hydrangea. The absolute configuration was determined by comparison of experimental and calculated electronic circular dichroism (ECD) spectra. In vitro activity against Plasmodium falciparum K1 strain, Trypanosoma brucei rhodesiense STIB 900 strain, and cytotoxicity in rat myoblast (L6) cells were determined. Compounds 1 and 2 showed in vitro antiplasmodial activity, with IC50 values of 1.43 and 0.18 μM and selectivity indices (SI) of 86.2 and 69.6, respectively. IC50 values against T. brucei rhodesiense were found to be 4.33 and 15.92 μM, respectively.

摘要

salvadione C（1）和 perovskone B（2）是两种从绣球状丹参的抗疟正己烷提取物中分离得到的具有罕见碳骨架的新三萜类化合物。通过比较实验和计算的电子圆二色性（ECD）谱确定了绝对构型。测定了对疟原虫 falciparum K1 株、布氏锥虫 rhodesiense STIB 900 株的体外活性和在大鼠成肌细胞（L6）中的细胞毒性。化合物 1 和 2 表现出体外抗疟活性，IC50 值分别为 1.43 和 0.18 μM，选择性指数（SI）分别为 86.2 和 69.6。对 T. brucei rhodesiense 的 IC50 值分别为 4.33 和 15.92 μM。