Asghari Behvar, Salehi Peyman, Sonboli Ali, Nejad Ebrahimi Samad
Department of Plant Production and Breeding, Faculty of Engineering and Technology, Imam Khomeini International University, Qazvin, Iran. ; Department of Phytochemistry, Medicinal Plants and Drugs Research Institute, Shahid Beheshti University, G. C., Tehran, Iran.
Department of Phytochemistry, Medicinal Plants and Drugs Research Institute, Shahid Beheshti University, G. C., Tehran, Iran.
Iran J Pharm Res. 2015 Spring;14(2):609-15.
It is believed that the inhibition of carbohydrate hydrolyzing enzymes including α-amylase and α-glucosidase is one of the therapeutic approaches to decrease the postprandial glucose level after a meal, especially in the people with type 2 diabetes. Medicinal plants and their extracts are one of the main sources to find new inhibitors to the enzymes. In our study four flavonoids, namely luteolin 7-O-glucoside (1), luteolin 7-O-glucuronide (2), diosmetin 7-O-glucuronide (3) and salvigenin (4) were isolated from aerial parts of Salvia chloroleuca. The inhibitory activity of these compounds against α-amylase and α-glucosidase were evaluated. Compounds 1, 2 and 3 showed potent α-glucosidase inhibitory effect with IC50 values of 18.3, 14.7, and 17.1 µM, respectively. Also these compounds exhibited moderate α-amylase activity with IC50 values 81.7, 61.5, and 76.3 µM, respectively.
据信，抑制包括α-淀粉酶和α-葡萄糖苷酶在内的碳水化合物水解酶是降低餐后餐后血糖水平的治疗方法之一，尤其是对于2型糖尿病患者。药用植物及其提取物是寻找这些酶新抑制剂的主要来源之一。在我们的研究中，从白花丹参地上部分分离出四种黄酮类化合物，即木犀草素7-O-葡萄糖苷（1）、木犀草素7-O-葡萄糖醛酸苷（2）、香叶木素7-O-葡萄糖醛酸苷（3）和 salvigenin（4）。评估了这些化合物对α-淀粉酶和α-葡萄糖苷酶的抑制活性。化合物1、2和3表现出较强的α-葡萄糖苷酶抑制作用，IC50值分别为18.3、14.7和17.1μM。此外，这些化合物还表现出中等程度的α-淀粉酶活性，IC50值分别为81.7、61.5和76.3μM。
