van Berge-Henegouwen G P, Huybregts A W, van de Werf S, Demacker P, Schade R W
Am J Clin Nutr. 1979 Apr;32(4):794-8. doi: 10.1093/ajcn/32.4.794.
Feeding of a chemically standardized coarse wheat bran product in a dose of 0.5 g/kg body weight per day over a period of 4 weeks in young healthy male volunteers did cause a significant reduction in total serum cholesterol as well as in total serum triglycerides of 10 and 24%, respectively. Very low density lipoprotein-, high density lipoprotein-, and low density lipoprotein-cholesterol levels tended to diminish during bran feeding. The most marked reduction was observed in the high density lipoprotein- cholesterol fraction. Although the duration of this study was relatively short, it is concluded, that these results could have therapeutic consequences for the dietary management of hyperlipidemia. However, the lowering of high density lipoprotein-cholesterol could also be interpreted as unfavorable since an inverse relationship between high density lipoprotien-cholesterol levels and the occurrence of coronary heart disease has been established.
在年轻健康男性志愿者中，连续4周每天以0.5克/千克体重的剂量喂食化学标准化的粗麦麸产品，确实导致总血清胆固醇以及总血清甘油三酯分别显著降低了10%和24%。在喂食麸皮期间，极低密度脂蛋白胆固醇、高密度脂蛋白胆固醇和低密度脂蛋白胆固醇水平趋于下降。在高密度脂蛋白胆固醇部分观察到最显著的降低。尽管这项研究的持续时间相对较短，但可以得出结论，这些结果可能对高脂血症的饮食管理具有治疗意义。然而，高密度脂蛋白胆固醇的降低也可以被解释为不利的，因为高密度脂蛋白胆固醇水平与冠心病的发生之间已确立了反比关系。
