Pommergaard H C, Rosenberg J, Schumacher-Petersen C, Achiam M P
Center for Perioperative Optimization, Department of Surgical Gastroenterology D, Herlev Hospital, University of Copenhagen, Herlev, Denmark.
Eur Surg Res. 2011;47(3):173-81. doi: 10.1159/000330748. Epub 2011 Sep 30.
BACKGROUND/AIMS: Animal models are valuable for studying pathogenic factors and preventive measures for colon anastomotic leakage. The suitability of the species as models varies greatly; however, no consensus exists on which species to use. The aim of this review was to evaluate different experimental animals for the study of clinical colon anastomotic leakage.
PubMed and REX database were searched up to October 2010 to identify studies evaluating clinical colon anastomotic leakage in animal models and textbooks on experimental animals, respectively.
Functional models of clinical colon anastomotic leakage have been developed in the mouse, pig, rat, dog and rabbit. However, extreme interventions are needed in order to produce clinical leakage in the rat.
Despite the wide use of the rat in this field of research, it seems that its resistance to intra-abdominal infection makes clinical leakage difficult to produce thus rendering the rat unsuited as a model. On the basis of the available literature, we recommend using mice as models mimicking clinical colon anastomotic leakage. Pigs may be an alternative; however, the existing models in this animal are less validated and clinically relevant.
背景/目的：动物模型对于研究结肠吻合口漏的致病因素和预防措施具有重要价值。不同物种作为模型的适用性差异很大；然而，对于使用哪种物种尚无共识。本综述的目的是评估用于研究临床结肠吻合口漏的不同实验动物。
检索截至2010年10月的PubMed和REX数据库，分别以确定评估动物模型中临床结肠吻合口漏的研究以及实验动物相关教科书。
已在小鼠、猪、大鼠、狗和兔子中建立了临床结肠吻合口漏的功能模型。然而，为了在大鼠中产生临床漏，需要采取极端干预措施。
尽管大鼠在该研究领域被广泛使用，但似乎其对腹腔内感染的抵抗力使得临床漏难以产生，因此大鼠不适合作为模型。根据现有文献，我们建议使用小鼠作为模拟临床结肠吻合口漏的模型。猪可能是一种替代选择；然而，该动物现有的模型验证较少且临床相关性较低。
