State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing 100191, China.
Fitoterapia. 2012 Jan;83(1):44-8. doi: 10.1016/j.fitote.2011.09.010. Epub 2011 Sep 24.
Two new flavonoids, wushanicaritin (1) and wushankaempferol (2), along with 24 known flavonoids were isolated from the whole herb of Epimedium wushanense T.S. Ying (Berberidaceae). On the basis of NMR and ESI-MS spectroscopic analysis, structures of compounds 1 and 2 were elucidated as 8-γ-hydroxy-γ,γ-dimethylpropyl-3,5,7-trihydroxy-4'- methoxyflavone and kaempferol 3-O-α-l-[2,3-di-O-β-D-(6-E-p-coumaroyl) glucopyranosyl]-rhamnopyranosyl-7-O-α-L-rhamnopyranoside, respectively. DPPH radical scavenging activity tests indicated that 1 (IC(50) 35.3 μM) exhibited antioxidant activity comparable to Vitamin C (IC(50) 32.0 μM), while 2 (IC(50) 443.7 μM) showed weak activity.
从巫山淫羊藿（Berberidaceae）全草中分离得到两种新的类黄酮化合物，即巫山皮定醇（1）和巫山山奈酚（2），以及 24 种已知的类黄酮化合物。根据 NMR 和 ESI-MS 光谱分析，确定化合物 1 和 2 的结构分别为 8-γ-羟基-γ,γ-二甲基丙基-3,5,7-三羟基-4'-甲氧基黄酮和山奈酚 3-O-α-l-[2,3-二-O-β-D-（6-E-对香豆酰基）吡喃葡萄糖基]-鼠李吡喃糖苷-7-O-α-L-鼠李吡喃糖苷，分别。DPPH 自由基清除活性测试表明，1（IC（50）35.3 μM）具有与维生素 C（IC（50）32.0 μM）相当的抗氧化活性，而 2（IC（50）443.7 μM）则表现出较弱的活性。
