Amzerin Mounia, Fadoukhair Zouhour, Belbaraka Rhizlane, Iraqui Meryem, Boutayeb Saber, M'rabti Hind, Kebdani Tayeb, Hassouni Khaled, Benjaafar Najib, El Gueddari Brahim K, Errihani Hassan
Department of Medical Oncology, National Institute of Oncology, Rabat, Morocco.
J Med Case Rep. 2011 Oct 3;5:491. doi: 10.1186/1752-1947-5-491.
Ameloblastoma is a rare benign odontogenic tumor with locally aggressive behavior and a high recurrence rate. When metastases occur, which are uncommon, lungs constitute the most frequent site involved. Malignant ameloblastomas are different from ameloblastic carcinomas. Malignant ameloblastomas are tumors considered metastatic despite the appearance of well-differentiated or benign histology, while ameloblastic carcinomas are histologically malignant in both primary and metastatic sites.
A 24-year-old Moroccan man presented a malignant ameloblastoma of the mandible. The tumor was entirely resected. Five years later, a local recurrence occurred. Our patient was treated by exclusive radiotherapy with persistence of a residual disease. After two years he developed multiple lung metastases. Our patient received a combination chemotherapy using doxorubicin and cisplatin.
Less than 50 cases of ameloblastoma with metastases have been reported. There is still no standard treatment for metastatic ameloblastoma. Only through continuous reporting of such cases will clinicians be able to draw an optimal strategy for management of this pathology.
成釉细胞瘤是一种罕见的良性牙源性肿瘤，具有局部侵袭性且复发率高。发生转移的情况并不常见，肺部是最常受累的部位。恶性成釉细胞瘤与成釉细胞癌不同。恶性成釉细胞瘤是尽管组织学表现为分化良好或良性但仍被认为发生转移的肿瘤，而成釉细胞癌在原发部位和转移部位的组织学均为恶性。
一名24岁的摩洛哥男性患有下颌骨恶性成釉细胞瘤。肿瘤被完全切除。五年后，出现局部复发。我们的患者接受了单纯放疗，但仍有残留病灶。两年后，他出现了多发肺转移。我们的患者接受了使用阿霉素和顺铂的联合化疗。
已报道的成釉细胞瘤转移病例少于50例。对于转移性成釉细胞瘤仍没有标准的治疗方法。只有通过持续报告此类病例，临床医生才能制定出针对这种病理情况的最佳管理策略。
