使用微透析分析的生化标志物与创伤性脑损伤的结果。
Biochemical markers analyzed using microdialysis and traumatic brain injury outcomes.
作者信息
Karathanou A, Paterakis K, Pakopoulou M, Tasiou A, Hadjigeorgiou G, Chovas A, Paraforos G, Fountas K, Komnos A
机构信息
Intensive Care Unit, Achillopoulio General Hospital, Volos, Greece.
出版信息
J Neurosurg Sci. 2011 Sep;55(3):173-7.
AIM
Traumatic brain injury is a leading cause of disability and mortality among young people. Multiparametric cerebral bedside monitoring is a safe and promising technique for preventing secondary brain damage. The objective of this study was to investigate the usefulness of cerebral microdialysis in predicting the outcomes of patients with traumatic brain injury.
METHODS
Thirty-eight patients (33 males) were included in the study. The GCS on admission was ≤8. The outcome was assessed using the GOS over six months of follow-up.
RESULTS
Among the patients included, 18 had a favorable outcome (GOS=4.5) and the remaining 20 had an unfavorable outcome. L/P ratio and glycerol concentration were statistically significantly higher in the patients with unfavorable prognosis.
CONCLUSION
Biochemical parameters analysed using microdialysis could serve as predictor indexes of clinical outcome several months after the injury.
目的
创伤性脑损伤是年轻人致残和致死的主要原因。多参数床边脑监测是预防继发性脑损伤的一种安全且有前景的技术。本研究的目的是探讨脑微透析在预测创伤性脑损伤患者预后方面的实用性。
方法
本研究纳入了38例患者（33例男性）。入院时格拉斯哥昏迷量表（GCS）评分≤8分。通过在六个月的随访期内使用格拉斯哥预后量表（GOS）评估预后。
结果
在纳入的患者中，18例预后良好（GOS = 4.5），其余20例预后不良。预后不良的患者中，乳酸/丙酮酸（L/P）比值和甘油浓度在统计学上显著更高。
结论
使用微透析分析的生化参数可作为损伤后数月临床预后的预测指标。
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