Department of Geriatrics, West China Hospital, Sichuan University, China.
Aging Clin Exp Res. 2012 Apr;24(2):139-44. doi: 10.3275/8018. Epub 2011 Oct 3.
In previous studies, Pro12Ala polymorphism in peroxisome proliferator- activated receptors gamma 2 (PPAR-γ2) was shown to be associated with both longevity and metabolic syndrome, which was closely related with hyperuricemia. We examined long-lived subjects (≥90 years), to ascertain whether the polymorphism is associated with the level of serum uric acid (SUA).
The present study analysed data from a survey conducted in 2005 on all residents aged 90 years or more in a district with 2,311,709 inhabitants.
The sample comprised 669 unrelated Chinese participants (aged 90-108 years, mean: 93.54±3.53 years; 67.2% women). The genotype frequencies of the Pro12Ala polymorphism were 0% Ala12Ala and 9.0% Pro12Ala, 91.0% Pro12Pro. Between men or women, and between subjects who were or were not 12Ala carriers, neither in SUA levels nor the prevalence of hyperuricemia were significant. Between subjects with and without hyperuricemia, the difference in prevalence of 12Ala carriers was also non-significant. Unadjusted and adjusted multiple logistic regressions showed that the odds ratios (OR) for hyperuricemia were not associated with Pro12Ala polymorphism in PPAR-γ2.
In Chinese nonagenarians and centenarians, SUA levels are not associated with polymorphism in PPAR-γ2.
先前的研究表明，过氧化物酶体增殖物激活受体 γ2（PPAR-γ2）中的 Pro12Ala 多态性与长寿和代谢综合征有关，而代谢综合征与高尿酸血症密切相关。我们检查了长寿受试者（≥90 岁），以确定该多态性是否与血清尿酸（SUA）水平有关。
本研究分析了 2005 年对一个拥有 2311709 名居民的地区所有 90 岁及以上居民进行的一项调查的数据。
样本包括 669 名无血缘关系的中国参与者（年龄 90-108 岁，平均：93.54±3.53 岁；67.2%为女性）。Pro12Ala 多态性的基因型频率为 0% Ala12Ala 和 9.0% Pro12Ala，91.0% Pro12Pro。无论男性还是女性，以及是否为 12Ala 携带者的受试者，SUA 水平或高尿酸血症的患病率均无显著差异。在有或没有高尿酸血症的受试者之间，12Ala 携带者的患病率差异也无统计学意义。未调整和调整后的多因素逻辑回归显示，高尿酸血症的比值比（OR）与 PPAR-γ2 中的 Pro12Ala 多态性无关。
在中国的 90 岁和 100 岁以上人群中，SUA 水平与 PPAR-γ2 中的多态性无关。
