用于结肠靶向给药的聚合物。

Rajpurohit H, Sharma P, Sharma S, Bhandari A

Faculty of Pharmaceutical Sciences, Jodhpur National University, Jodhpur - 342 008, India.

Indian J Pharm Sci. 2010 Nov;72(6):689-96. doi: 10.4103/0250-474X.84576.

The colon targeted drug delivery has a number of important implications in the field of pharmacotherapy. Oral colon targeted drug delivery systems have recently gained importance for delivering a variety of therapeutic agents for both local and systemic administration. Targeting of drugs to the colon via oral administration protect the drug from degradation or release in the stomach and small intestine. It also ensures abrupt or controlled release of the drug in the proximal colon. Various drug delivery systems have been designed that deliver the drug quantitatively to the colon and then trigger the release of drug. This review will cover different types of polymers which can be used in formulation of colon targeted drug delivery systems.

结肠靶向给药在药物治疗领域具有许多重要意义。口服结肠靶向给药系统最近在递送用于局部和全身给药的多种治疗剂方面变得日益重要。通过口服将药物靶向递送至结肠可保护药物在胃和小肠中不被降解或释放。它还可确保药物在近端结肠中突然或可控地释放。已经设计了各种药物递送系统，可将药物定量递送至结肠，然后触发药物释放。本综述将涵盖可用于结肠靶向给药系统制剂的不同类型聚合物。