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呼吸机大流行分配模型对患有支气管肺发育不良的婴儿不利。

The Pandemic Allocation of Ventilators Model Penalizes Infants with Bronchopulmonary Dysplasia.

作者信息

Sundaram Anupama, Fanaroff Jonathan M, Wilson-Costello Deanne, Alberts Melissa, Shiswawala Naini, Stern Noam, Ryan Rita M

机构信息

Department of Neonatology, University Hospitals Rainbow Babies and Children's Hospital, Case Western Reserve University, Cleveland, OH 44106, USA.

出版信息

Children (Basel). 2023 Aug 17;10(8):1404. doi: 10.3390/children10081404.

Abstract

During the COVID-19 pandemic, institutions developed ventilator allocation models. In one proposed model, neonates compete with adults for ventilators using a scoring system. Points are given for conditions that increase one- and five-year (y) mortality. For example, comparable points were added for adult conditions with mortality of 71.3% and for neonates with moderate or severe bronchopulmonary dysplasia (mod/sBPD). We hypothesized that this model overestimates mortality in neonates with BPD and would penalize these infants unfairly. There was little information available on 1 y and 5 y mortality risk for mod/sBPD. To evaluate this allocation protocol, a retrospective chart review was performed on infants born ≥22 weeks and weighing <1500 g admitted to Rainbow Babies and Children's Hospital in 2015 to identify babies with BPD. The main outcomes were 1 and 5 y mortality. In 2015, 28 infants were diagnosed with mod/s BPD based on NIH 2001 definition; 4 infants had modBPD and 24 had sBPD. All infants (100%) with modBPD survived to 5 y; 2 infants with sBPD died by 1 y (8%) and 22 survived (92%) to 1 y; 3 died (12.5%) by 5 y; and at least 13 survived (54%) to 5 y. Infants with mod/s BPD had lower-than-predicted 1 and 5 y mortality, suggesting the points assigned in the model are too high for these conditions. We believe this model would unfairly penalize these babies.

摘要

在新冠疫情期间,各机构开发了呼吸机分配模型。在一个提议的模型中,新生儿使用评分系统与成人竞争呼吸机。根据增加1年和5年死亡率的情况给予分数。例如,对于死亡率为71.3%的成人疾病和患有中度或重度支气管肺发育不良(mod/sBPD)的新生儿给予相同的分数。我们假设该模型高估了患有BPD的新生儿的死亡率,会不公平地惩罚这些婴儿。关于mod/sBPD的1年和5年死亡风险的信息很少。为了评估这个分配方案,我们对2015年入住彩虹婴儿与儿童医院、孕周≥22周且体重<1500克的婴儿进行了回顾性病历审查,以确定患有BPD的婴儿。主要结局是1年和5年死亡率。2015年,根据美国国立卫生研究院2001年的定义,28名婴儿被诊断为mod/s BPD;4名婴儿患有modBPD,24名患有sBPD。所有患有modBPD的婴儿(100%)存活至5岁;2名患有sBPD的婴儿在1岁前死亡(8%),22名存活至1岁(92%);3名在5岁前死亡(12.5%);至少13名存活至5岁(54%)。患有mod/s BPD的婴儿1年和5年死亡率低于预测值,这表明该模型中为这些情况分配的分数过高。我们认为这个模型会不公平地惩罚这些婴儿。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a325/10452995/bf3f05484fdc/children-10-01404-g001.jpg

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