[荧光原位杂交技术在血吸虫生物学中的应用与进展]

[Application and progress of fluorescence in situ hybridization in schistosome biology].

作者信息

Mo Xiao-Jin, Feng Zheng, Hu Wei

机构信息

National Institute of Parasitic Diseases, Chinese Center for Disease Control and Prevention, Shanghai 200025, China.

出版信息

Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi. 2011 Jun;29(3):224-8, 232.

PMID:21970116

Abstract

Schistosomiasis is one of the most serious parasitic diseases. Schistosome genes research provides the basis for study of schistosomiasis diagnosis, vaccine and drug targets. Fluorescence in situ hybridization (FISH) in schistosome focuses on researches of location of functional genes on chromosomes, genome physical mapping and chromosome identification. This article reviews the application of FISH in schistosome biology and its potential development.

摘要

血吸虫病是最严重的寄生虫病之一。血吸虫基因研究为血吸虫病诊断、疫苗和药物靶点的研究提供了基础。血吸虫的荧光原位杂交（FISH）主要集中于功能基因在染色体上的定位、基因组物理图谱绘制及染色体鉴定等研究。本文综述了FISH在血吸虫生物学中的应用及其潜在发展。