Department of Pathology, New York University Langone Medical Center, New York, NY 10016, USA.
Arch Pathol Lab Med. 2011 Oct;135(10):1320-8. doi: 10.5858/arpa.2011-0021-RA.
Knowledge of the etiology and pathogenesis of chronic viral hepatitis has grown immensely during the past 50 years. The terminology used to assess liver biopsies with chronic viral hepatitis and the role of the liver biopsy itself have also evolved during this time. Although the focus of much discussion regarding diagnostic assessment of liver biopsies in patients with viral hepatitis has been on grading of activity and staging of fibrosis, each biopsy is also an opportunity to assess many other important features.
To discuss opportunities provided by biopsies to assess features such as the presence of virus-associated premalignant or malignancy-related changes, and the presence of other concomitant diseases, including fatty liver disease of diverse causes, and hemochromatosis, hereditary or otherwise.
The data were obtained from published literature and professional experience.
The evaluation of liver biopsies with chronic viral hepatitis has evolved beyond grading and staging. Pathologists need to be aware of the other features that may have important clinical implications.
在过去的 50 年中，人们对慢性病毒性肝炎的病因和发病机制有了深入的了解。在此期间，用于评估慢性病毒性肝炎肝活检的术语以及肝活检本身的作用也发生了演变。尽管关于病毒性肝炎患者肝活检诊断评估的讨论重点主要集中在活动度分级和纤维化分期上，但每次活检也是评估许多其他重要特征的机会。
讨论活检提供的机会，以评估与病毒相关的癌前病变或与恶性肿瘤相关的变化的存在，以及其他伴随疾病的存在，包括不同病因的脂肪肝和血色病，遗传性或其他原因。
数据来源于已发表的文献和专业经验。
慢性病毒性肝炎肝活检的评估已经超越了分级和分期。病理学家需要了解可能具有重要临床意义的其他特征。
