Discipline of Exercise Sciences, School of Medical Sciences & Health Innovations Research Institute, RMIT University, Melbourne, Victoria, Australia.
J Endocrinol Invest. 2012 Jul;35(7):665-9. doi: 10.3275/7972. Epub 2011 Sep 30.
Regular resistance exercise completed for a number of weeks has been shown to increase insulin sensitivity and reduce the risk of diabetes-related complications. However, the acute responses to resistance exercise have not been adequately investigated in relation to training frequency.
To investigate the changes to insulin sensitivity in apparently healthy individuals following a single session of unaccustomed resistance exercise.
Ten sedentary, apparently healthy individuals performed a baseline oral glucose tolerance test and maximal strength testing. Participants then performed a single session of moderate-high intensity resistance exercise which was followed by 4 consecutive days of oral glucose tolerance testing, for which participants replicated their initial diet. Mean estimated insulin sensitivity change scores from baseline values and their 95% confidence intervals were compared to the previously determined values for a clinically meaningful change.
Two participants were identified as having hyperinsulinemia and their data were therefore removed from the main analysis. There was a clinically meaningful increase in insulin response (mean >7237 pmol·l⁻¹·120 min⁻¹) on all days following the exercise session and a clinically meaningful increase in glucose response (mean >81 mmol·l⁻¹·120 min⁻¹) on only the 3rd day following exercise. These changes suggest a potentially adverse short-term effect. Additionally, the 2 individuals with hyperinsulinemia displayed more extreme results.
These results suggest that insulin sensitivity may be impaired following a single session of unaccustomed resistance exercise for approximately 4 days in healthy untrained, older individuals. Further research is required for individuals with hyperinsulinemia.
数周有规律的抗阻运动已被证明可提高胰岛素敏感性，降低糖尿病相关并发症的风险。然而，抗阻运动的急性反应与训练频率的关系尚未得到充分研究。
探讨单次不习惯的抗阻运动后健康个体的胰岛素敏感性变化。
10 名久坐、健康的个体进行了基线口服葡萄糖耐量试验和最大力量测试。参与者随后进行了一次中等高强度的抗阻运动，之后连续 4 天进行口服葡萄糖耐量试验，参与者在这 4 天中复制了他们的初始饮食。从基线值和 95%置信区间的平均估计胰岛素敏感性变化分数与之前确定的临床有意义的变化值进行了比较。
有 2 名参与者被确定为高胰岛素血症，因此他们的数据从主要分析中删除。在运动后的所有日子里，胰岛素反应都有明显的临床意义增加（平均 >7237 pmol·l⁻¹·120 min⁻¹），而仅在运动后的第 3 天，葡萄糖反应才有明显的临床意义增加（平均 >81 mmol·l⁻¹·120 min⁻¹）。这些变化表明可能存在短期不良影响。此外，2 名高胰岛素血症患者表现出更极端的结果。
这些结果表明，在健康未经训练的老年个体中，单次不习惯的抗阻运动可能会在大约 4 天内损害胰岛素敏感性。需要对高胰岛素血症患者进行进一步研究。
