Clark G E, Troullos E S
Block Drug Company, Jersey City, New Jersey.
Dent Clin North Am. 1990 Jul;34(3):531-44.
A dentinal hypersensitivity study is really a clinical pain study. The fundamental difficulties in reproducibly and reliably measuring pain impact heavily on the study. Other critical issues include investigator and subject selection, study design, randomization strategy, study duration, sample size, and statistical analysis. This article discusses principles involved in establishing the efficacy of a desensitizing agent.
牙本质过敏研究实际上是一项临床疼痛研究。可重复性和可靠地测量疼痛方面的根本困难对该研究产生了重大影响。其他关键问题包括研究者和受试者的选择、研究设计、随机化策略、研究持续时间、样本量以及统计分析。本文讨论了确定脱敏剂疗效所涉及的原则。
