认知事件相关电位：阿尔茨海默病各阶段突触功能障碍的生物标志物。
Cognitive event-related potentials: biomarkers of synaptic dysfunction across the stages of Alzheimer's disease.
机构信息
Department of Neurology, University of California, Davis, CA, USA.
出版信息
J Alzheimers Dis. 2011;26 Suppl 3(0 3):215-28. doi: 10.3233/JAD-2011-0047.
Abstract
Cognitive event-related brain potential (ERP) studies of decision-making and attention, language, and memory impairments in Alzheimer's disease (AD) and mild cognitive impairment (MCI) are reviewed. Circumscribed lesions of the medial temporal lobe (MTL), as may be the case in individuals with amnestic MCI, generally produce altered plasticity of the late positive P600 component, with relative sparing of earlier sensory ERP components. However, as the neuropathology of AD extends to neocortical association areas, abnormalities of the P300 and N400 (and perhaps even P50) become more common. Critically, ERP studies of individuals at risk for AD may reveal neurophysiological changes prior to clinical deficits, which could advance the early detection and diagnosis of "presymptomatic AD".
摘要
本文回顾了阿尔茨海默病（AD）和轻度认知障碍（MCI）患者决策和注意、语言及记忆损伤的认知事件相关脑电位（ERP）研究。内侧颞叶（MTL）的局灶性病变，如遗忘型 MCI 个体中可能出现的情况，通常会导致晚期正相关 P600 成分的可塑性改变，而早期感觉 ERP 成分相对保留。然而，随着 AD 的神经病理学扩展到新皮质联合区，P300 和 N400（甚至可能是 P50）的异常变得更为常见。关键的是，AD 高危个体的 ERP 研究可能会在出现临床缺陷之前揭示神经生理变化，从而有助于 AD 的早期发现和诊断。
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