Universidade Estadual da Paraíba, Núcleo de Estudos e Pesquisas Epidemiológicas, Campina Grande, PB, Brazil.
Arq Bras Cardiol. 2011 Nov;97(5):380-9. doi: 10.1590/s0066-782x2011005000089. Epub 2011 Sep 30.
Individuals with insulin resistance are more prone to the development of metabolic syndrome (MS), Type 2 Diabetes Mellitus and Cardiovascular Disease (CVD) OBJECTIVE: To evaluate the association between insulin resistance (IR) and metabolic syndrome components.
Cross-sectional study of 196 individuals between 2 and 18 years, treated at the Brazilian Public Healthcare system. The association of IR with the MS components was evaluated by Chi-square test, adopting the Homeostasis model assessment-insulin resistance (HOMA-IR) value > 2.5, and by analysis of variance (ANOVA) and Tukey's test, by comparing the means of the components in the HOMA-IR quartiles. Statistical analysis was performed using SPSS 17.0 software and significance level was set at 5%.
IR was observed in 41.3% of the studied population and was associated with age between 10-18 years (p = 0.002 PR = 3.2), to MS in both sexes [Male (p = 0.022 PR = 3.7) and female (p = 0.007 PR = 2.7)] and altered triglycerides (p = 0.005 PR = 2.9) in females. The mean values of the MS components differed significantly between HOMA-IR quartiles (p <0.01), except for HDL-cholesterol.
Insulin resistance can be considered a marker of cardiovascular risk.
胰岛素抵抗个体更容易发展为代谢综合征（MS）、2 型糖尿病和心血管疾病（CVD）。
评估胰岛素抵抗（IR）与代谢综合征成分之间的关系。
这是一项在巴西公共医疗系统中接受治疗的 196 名 2 至 18 岁个体的横断面研究。采用稳态模型评估胰岛素抵抗（HOMA-IR）值＞2.5 的卡方检验评估 IR 与 MS 成分的相关性，并采用方差分析（ANOVA）和 Tukey 检验比较 HOMA-IR 四分位组的成分均值。统计分析采用 SPSS 17.0 软件，显著性水平设为 5%。
研究人群中 41.3%存在 IR，与 10-18 岁年龄相关（p=0.002 PR=3.2），与男性（p=0.022 PR=3.7）和女性（p=0.007 PR=2.7）的 MS 以及女性的甘油三酯改变（p=0.005 PR=2.9）均相关。HOMA-IR 四分位组之间 MS 成分的平均值差异有统计学意义（p＜0.01），但高密度脂蛋白胆固醇除外。
胰岛素抵抗可被视为心血管风险的标志物。
