Rosini Nilton, Moura Solange A Z Oppermann, Rosini Rodrigo Diegoli, Machado Marcos José, Silva Edson Luiz da
Universidade Federal de Santa Catarina, Florianópolis, SC, BR.
16ª Secretaria de Estado de Desenvolvimento Regional em Brusque, SC, BR.
Arq Bras Cardiol. 2015 Jul;105(1):37-44. doi: 10.5935/abc.20150040. Epub 2015 May 8.
The risk factors that characterize metabolic syndrome (MetS) may be present in childhood and adolescence, increasing the risk of cardiovascular disease in adulthood.
Evaluate the prevalence of MetS and the importance of its associated variables, including insulin resistance (IR), in children and adolescents in the city of Guabiruba-SC, Brazil.
Cross-sectional study with 1011 students (6-14 years, 52.4% girls, 58.5% children). Blood samples were collected for measurement of biochemical parameters by routine laboratory methods. IR was estimated by the HOMA-IR index, and weight, height, waist circumference and blood pressure were determined. Multivariate logistic regression models were used to examine the associations between risk variables and MetS.
The prevalence of MetS, IR, overweight and obesity in the cohort were 14%, 8.5%, 21% and 13%, respectively. Among students with MetS, 27% had IR, 33% were overweight, 45.5% were obese and 22% were eutrophic. IR was more common in overweight (48%) and obese (41%) students when compared with eutrophic individuals (11%; p = 0.034). The variables with greatest influence on the development of MetS were obesity (OR = 32.7), overweight (OR = 6.1), IR (OR = 4.4; p ≤ 0.0001 for all) and age (OR = 1.15; p = 0.014).
There was a high prevalence of MetS in children and adolescents evaluated in this study. Students who were obese, overweight or insulin resistant had higher chances of developing the syndrome.
代谢综合征（MetS）的特征性危险因素可能在儿童期和青少年期就已出现，这会增加成年后患心血管疾病的风险。
评估巴西圣卡塔琳娜州瓜比鲁巴市儿童和青少年中代谢综合征的患病率及其相关变量（包括胰岛素抵抗（IR））的重要性。
对1011名学生（6 - 14岁，52.4%为女孩，58.5%为儿童）进行横断面研究。通过常规实验室方法采集血样以测量生化参数。通过HOMA - IR指数估算胰岛素抵抗，并测定体重、身高、腰围和血压。使用多变量逻辑回归模型来检验风险变量与代谢综合征之间的关联。
该队列中代谢综合征、胰岛素抵抗、超重和肥胖的患病率分别为14%、8.5%、21%和13%。在患有代谢综合征的学生中，27%有胰岛素抵抗，33%超重，45.5%肥胖，22%营养正常。与营养正常的个体（11%；p = 0.034）相比，胰岛素抵抗在超重（48%）和肥胖（41%）的学生中更为常见。对代谢综合征发展影响最大的变量是肥胖（OR = 32.7）、超重（OR = 6.1）、胰岛素抵抗（OR = 4.4；所有p≤0.0001）和年龄（OR = 1.15；p = 0.014）。
本研究评估的儿童和青少年中代谢综合征患病率较高。肥胖、超重或有胰岛素抵抗的学生患该综合征的几率更高。
