Hanneken S, Rütten A, Eigelshoven S, Braun-Falco M, Pasternack S M, Ruzicka T, Nöthen M M, Betz R C, Kruse R
Hautklinik, Universitätsklinikum Düsseldorf, Moorenstr. 5, 40225 Düsseldorf.
Hautarzt. 2011 Nov;62(11):842-51. doi: 10.1007/s00105-011-2222-x.
Galli-Galli disease, a rare genodermatosis belonging to the spectrum of reticulate pigment dermatoses, is classified as an acantholytic variant of Dowling-Degos disease on the basis of its characteristic clinical and histological findings. In the context of this case series, Galli-Galli disease is characterized in detail based on the clinical and histopathological evaluation of 18 patients. The disease pattern is discussed in view of the current literature. In addition, a classification into two clinical subtypes is made and a genotype/phenotype correlation with mutations in the keratin 5 (KRT5) gene is established.
加里 - 加里病是一种罕见的遗传性皮肤病，属于网状色素性皮肤病范畴，根据其特征性的临床和组织学表现，被归类为道林 - 迪戈斯病的棘层松解变异型。在这个病例系列中，基于对18例患者的临床和组织病理学评估，对加里 - 加里病进行了详细的特征描述。结合当前文献对该病模式进行了讨论。此外，将其分为两种临床亚型，并建立了与角蛋白5（KRT5）基因突变的基因型/表型相关性。
