Department of Oncologic Imaging, National Cancer Center, Singapore; Center for Quantitative Biology, Duke-NUS Graduate Medical School, Singapore; School of Electrical and Electronic Engineering, Nanyang Technological University, Singapore.
J Magn Reson Imaging. 2011 Dec;34(6):1262-76. doi: 10.1002/jmri.22795. Epub 2011 Oct 3.
Tracer kinetic methods employed for quantitative analysis of dynamic contrast-enhanced (DCE) magnetic resonance imaging (MRI) share common roots with earlier tracer studies involving arterial-venous sampling and other dynamic imaging modalities. This article reviews the essential foundation concepts and principles in tracer kinetics that are relevant to DCE MRI, including the notions of impulse response and convolution, which are central to the analysis of DCE MRI data. We further examine the formulation and solutions of various compartmental models frequently used in the literature. Topics of recent interest in the processing of DCE MRI data, such as the account of water exchange and the use of reference tissue methods to obviate the measurement of an arterial input, are also discussed. Although the primary focus of this review is on the tracer models and methods for T(1) -weighted DCE MRI, some of these concepts and methods are also applicable for analysis of dynamic susceptibility contrast-enhanced MRI data.
示踪动力学方法被用于对动态对比增强磁共振成像（DCE MRI）进行定量分析，其与涉及动静脉采样和其他动态成像模式的早期示踪研究具有共同的根源。本文回顾了与 DCE MRI 相关的示踪动力学的基本基础概念和原理，包括脉冲响应和卷积的概念，这是 DCE MRI 数据分析的核心。我们进一步研究了在文献中经常使用的各种室模型的公式和解决方案。本文还讨论了 DCE MRI 数据处理中最近关注的主题，例如水交换的说明以及使用参考组织方法来避免测量动脉输入的问题。尽管本综述的主要重点是 T1 加权 DCE MRI 的示踪模型和方法，但其中一些概念和方法也适用于分析动态磁化率对比增强 MRI 数据。
