Key Laboratory of Analytical Chemistry for Biology and Medicine (Ministry of Education), Department of Chemistry, Wuhan University, Wuhan, P R China.
J Sep Sci. 2011 Nov;34(21):3083-91. doi: 10.1002/jssc.201100634. Epub 2011 Oct 4.
A novel magnetic material Fe(3)O(4)/SiO(2)/P(MAA-co-VBC-co-DVB) was prepared via the hypercrosslinking of its precursor which was produced via precipitation polymerization of methacrylic acid (MAA), vinylbenzyl chloride (VBC), and divinylbenzene (DVB) in the presence of Fe(3)O(4)/SiO(2) submicrospheres with the surface containing abundant reactive double bonds. The resultant sorbent was characterized by scan electron microscopy, N(2) adsorption, and Fourier transform infrared spectroscopy. It was found that this material had remarkable features such as large surface area (500 m(2)/g) and pore volume (0.32 cm(3)/g), as well as desirable chemical composition (including hydrophobic and ion-exchange moieties). Taking advantages of the Fe(3)O(4)/SiO(2)/P(MAA-co-VBC-co-DVB), a magnetic SPE (MSPE) coupled with capillary electrophoresis (CE) method was developed for the determination of illegal drugs in urine samples. The extraction time could be clearly shortened up to 3 min. The recoveries of these drug compounds were in the range of 84.0-123% with relative standard deviations ranging between 1.7 and 10.5%; the limit of detection was in the range of 4.0-6.0 μg/L. The proposed method is simple, effective, and low-cost, and provides an accurate and sensitive detection platform for abused drug analysis.
一种新型磁性材料 Fe(3)O(4)/SiO(2)/P(MAA-co-VBC-co-DVB) 是通过其前体的超交联制备的，该前体是通过在含有丰富反应性双键的 Fe(3)O(4)/SiO(2) 亚微米球存在下，由甲基丙烯酸 (MAA)、苯乙烯基氯 (VBC) 和二乙烯基苯 (DVB) 沉淀聚合而成。所得吸附剂通过扫描电子显微镜、N(2)吸附和傅里叶变换红外光谱进行了表征。结果表明，该材料具有显著的特点，如大表面积 (500 m(2)/g) 和孔体积 (0.32 cm(3)/g)，以及理想的化学成分 (包括疏水和亲脂性基团)。利用 Fe(3)O(4)/SiO(2)/P(MAA-co-VBC-co-DVB)，开发了一种磁性 SPE（MSPE）与毛细管电泳（CE）相结合的方法，用于测定尿液样品中的非法药物。萃取时间可明显缩短至 3 分钟。这些药物化合物的回收率在 84.0-123%之间，相对标准偏差在 1.7-10.5%之间；检测限在 4.0-6.0μg/L 范围内。该方法简单、有效、成本低，为滥用药物分析提供了一个准确、灵敏的检测平台。
