Kupryjańczyk J
Department of Pathomorphology, Medical School of Warsaw, Poland.
Int J Gynecol Pathol. 1990;9(3):263-71. doi: 10.1097/00004347-199007000-00006.
The expression of epidermal growth factor receptor (EGFR) was studied in the normal and inflamed cervix uteri, and the results were compared with estrogen receptor (ER) expression. The study was performed on fresh frozen specimens from 18 cases by means of immunohistochemistry, with application of EGFR1 antibody and an ER-ICA kit (Abbott, Wiesbaden, F.R.G.). The EGFR was expressed by the basal and parabasal layers of ectocervical and metaplastic epithelium and by reserve cells. No cyclic fluctuations in EGFR expression were noted. The glandular epithelium did not express EGFR. Some glands stained positive in the region of the basement membrane. Staining was not diminished in inflammatory foci, in contrast to ER expression, which was trace or absent. This was observed in both normal and dysplastic squamous epithelium. It may be assumed that the change of the normal relationship between ERs and EGFRs influences the process of proliferation and maturation of the squamous epithelium and may play a role in its disturbances.
研究了正常及炎症状态下子宫颈组织中表皮生长因子受体（EGFR）的表达情况，并将结果与雌激素受体（ER）的表达进行比较。采用免疫组织化学方法，应用EGFR1抗体和ER-ICA试剂盒（德国威斯巴登雅培公司），对18例新鲜冷冻标本进行研究。EGFR在外宫颈和化生上皮的基底层和副基底层以及储备细胞中表达。未观察到EGFR表达的周期性波动。腺上皮不表达EGFR。一些腺体在基底膜区域染色呈阳性。与ER表达（呈微量或无表达）不同，炎症灶中的染色并未减弱。在正常和发育异常的鳞状上皮中均观察到这种情况。可以推测，ER与EGFR之间正常关系的改变会影响鳞状上皮的增殖和成熟过程，并可能在其紊乱中起作用。
